A review on novel vesicular drug delivery: proniosomes

Nagarkar, Raj; Jakki, Satya Lavanya; Jawahar, N; Kuppusamy, Gowthamarajan

doi:10.3109/10717544.2013.841783

Cited by 100 publications

(61 citation statements)

References 44 publications

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“…Surfactant:alcohol:aqueous phase ratio in the final formulation was 5:5:4 w/w/w. If the drug is incompletely dissolved in the formulation, in such case both the drug and surfactants were dissolved first in ether or chloroform, followed by vacuum evaporation of the solvent (Vora et al, 1998;Gupta et al, 2007;Yasam et al, 2013;Ramesh et al, 2013).…”

Section: Preparation Of Proniosomesmentioning

confidence: 99%

“…To elucidate mode and mechanism of drug release, the dissolution profiles between the formulations were compared and statistically in vitro data was transformed; interpreted at graphical interface constructed using model independent various kinetic models like zero order, first order, Korsmeyer-peppa's and higuchi's model (Yasam et al, 2013). The zero order release Equation (1), where the drug release is independent of concentration.…”

Section: Release Kineticsmentioning

confidence: 99%

“…Proniosomes have high physical and chemical stability providing convenience in transfer, distribution, measuring, high shelf life, cost effective and storage making them more effective, attractive and industrial friendly product for large scale production (Yasam et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

et al. 2014

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Nifedipine is a calcium channel blocker extensively used in the treatment of anginal and hypertension. On oral administration it undergoes extensive first pass metabolism, which outweighs its absorbance through gastrointestinal tract (GIT) and bioavailability of the drug in systemic circulation. As an alternative to oral route transdermal route of drug delivery was developed. In the present investigation, proniosomes are prepared by varying the ratio of span-40, lecithin, aqueous phase and polymer. Formulation containing span-40, lecithin, isopropyl alcohol, 0.1% glycerol (5:5:4) and HPMC (2%) showed smaller vesicle size, high entrapment efficiency. The niosomal formation after hydration and their surface morphology of optimized formulation was studied by Motic and transmission electron microscopy. FTIR and differential scanning calorimetry studies were performed to unravel and understand the solid state properties of the drug and chemical interaction with formulation excipients. The ex-vivo Franzdiffusion studies were carried out in pH 6.8 using rat skin and the results showed better permeability of niosomes with good steady state flux and enhancement ratio suggesting the potential of proniosomal carriers for improved transdermal delivery of nifedipine. Skin irritation studies for 7 days, showed that the drug when formulated as proniosomes to be non-irritant with no erythemia development compared to pure drug. From the bio-distribution studies, the vesicles prepared with hydroxy propyl methyl cellulose with span-40 was found to be ideal batch as the concentration of drug at target site was higher.

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Section: Preparation Of Proniosomesmentioning

confidence: 99%

Section: Release Kineticsmentioning

confidence: 99%

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A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

et al. 2014

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“…Upon contact with the skin, these systems get hydrated under occlusion to form niosomes and absorbed to elicit systemic effects. [8] They easily permeate across the skin in the form of niosomes and release the encapsulated drug in controlled manner. The physical stability problems of aggregation, fusion and leaking could be efficiently trounced by this system.…”

Section: Introductionmentioning

confidence: 99%

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Lather¹,

Sharma²,

Pandita³

2016

Journal of Experimental Nanoscience

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Vesicular systems endow large opportunities for the transdermal delivery of therapeutics. The present study was designed to investigate the potential of a novel class of vesicular system 'proniosome' as a carrier for transdermal delivery of bromocriptine (BCT). Proniosome formulations were prepared by the coacervationphase separation method and the influence of factors like surfactant type and its amount, lipid concentration, cholesterol amount and drug content were studied. Span 60 was the most appropriate surfactant, and yielded vesicle size and percentage encapsulation efficiency of 1.3 mm and 98.9%, respectively. The developed system was characterised w.r.t. morphology, transition temperature, drug release, skin permeation and skin irritancy. Proniosomes exhibited a sustained release pattern of BCT in vitro. Skin permeation study revealed high penetration of proniosomes with sustained release of BCT through rat skin. The optimised proniosomal formulation showed enhanced transdermal flux of 16.15 mg/cm 2 /h as compared to 3.67 mg/cm 2 /h for drug dispersion. The developed formulations were observed as non-irritant to the rat skin and were found as quite stable at 4 and 25 C for 90 days w.r.t. vesicle size and drug content. The dried proniosomal formulation could act as a promising alternative to niosomes and preferably for transdermal delivery of BCT.

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“…Encapsulation of drug in niosomal formulations reduces the toxicity in various therapies and applications and also prolongs the encapsulated drug circulation time and changes drug distribution in the body. Niosomes as drug delivery vesicles increases absorption of some drugs through cell membranes and cellular uptake via endocytosis and so confines the drug in tissues and targeted organs (Yasam et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Ocular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studies

2017

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Context: Vesicular drug carriers for ocular delivery have gained a real potential. Proniosomal gels as ocular drug carriers have been proven to be an effective way to improve bioavailability and patient compliance. Objective: Formulation and in vitro/ex vivo/in vivo characterization of ketoconazole (KET)-loaded proniosomal gels for the treatment of ocular keratitis. Materials and methods: The effect of formulation variables; HLB value, type and concentration of non-ionic surfactants (Tweens, Spans, Brijs and Pluronics) with or without lecithin on the entrapment efficiency (EE%), vesicle size and in vitro KET release was evaluated. An ex vivo corneal permeation study to determine the level of KET in the external eye tissue of albino rabbits and an in vivo assessment of the level of KET in the aqueous humors were performed. Results and discussion: In vivo evaluation showed an increase in bioavailability up to 20-folds from the optimum KET proniosomal gel formula in the aqueous humor compared to drug suspension (KET-SP). The selected formulae were composed of spans being hydrophobic suggesting the potential use of a more hydrophobic surfactant as Span during the formulation of formulae. Factors that stabilize the vesicle membrane and increase the entrapment efficiency of KET (namely low HLB, long alkyl chain, high phase transition temperature) slowed down the release profile. Conclusions: Proniosomal gels as drug delivery carriers were proven to be a promising approach to increase corneal contact and permeation as well as retention time in the eye resulting in a sustained action and enhanced bioavailability.

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A review on novel vesicular drug delivery: proniosomes

Cited by 100 publications

References 44 publications

A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Ocular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studies

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