A review on ozone therapy in periodontitis

Abstract

The biologic process of osseointegration (bone to implant interface), in which the implant forms an intimate relationship with the bone, provides the foundation for modern dental implants. Osseointegration necessitates a varying length of healing time. Despite the high success and survival rates of dental implants, problems do occur, necessitating ongoing periodontal and prosthodontic care. This failure frequently results in "peri-implantitis," which affects the soft and hard tissues surrounding the osseointegrated implants, resulting in the formation of a peri implant pocket and bone loss. Decontamination is a difficult feature of surgical regenerative therapy for peri-implantitis that has an impact on its success. Because microbial biofilms play such a significant part in the aetiology of peri-implant illnesses, it has long been assumed that eliminating microbial pathogens would be beneficial.

Ozone therapy improves early stages of osseointegration in ovariectomized rats

“…Ozone has a direct impact on the immune system and cellular metabolic responses, notably by stimulating the proliferation of immune-active cells and enhancing the synthesis of biologically active substances such as interleukins, leukotrienes, and prostaglandins. 39 , 40 Furthermore, its role in promoting hypervascularization and subsequent tissue hyperoxygenation is crucial for effective bone repair.…”

Hydrogel films prepared from plant-seed mucilage: an emerging biopolymer for therapeutic applications

“…Its remarkable nutritional profile, which includes anti-bacterial, anti-inflammatory, anti-thrombotic, anti-cancer, and antiarrhythmic qualities, is another noteworthy aspect of it. [16][17][18][19][20] Previously, there have been works on the preparation of hydrogel using natural mucilages from fenugreek and flax seeds, but they have all been prepared in conjunction with an artificial cross-linker or grafted with another inorganic material. This limits the overall environmental-friendly property of using a natural hydrogel and also introduces complexity in preparation.…”

“…Its remarkable nutritional profile, which includes anti-bacterial, anti-inflammatory, anti-thrombotic, anti-cancer, and anti-arrhythmic qualities, is another noteworthy aspect of it. 16–20…”

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

“…For example, in periodontitis and gingival inflammatory disorders, ozone is widely used to reduce microbial biofilms. 9 In this circumstance, ozone exerts its pro-oxidant and anti-bacterial activity. 10 Actually, ozone has primarily a pro-oxidant nature, which only at low doses triggers the production of reactive oxygen species (ROS) at a level that makes these reactive compounds signaling molecules, more than damaging agents.…”