A Review on Pyridazinone Ring Containing Various Cardioactive Agents

Abstract

In this work, some pyridazinones were studied for their cardioactive activity. These compounds showed significant cardio-active action with respect to the regular used drugs. However, it was found that the existence of the pyridazine ring is a crucial necessity in the structure of these pyridazinonecompounds to show the improved cardioactive activities. It was also understood that the substitution of the different group on the pyridazinone ring with other related bioisosteres or isosteres along with the existence of pyridazine ring may provide better cardioactive compounds. Pyridazinoneis, a component of various cardio-active agents, which are in uses clinically or in clinical trials. These contain pimobendan, indolidan, levosimendan, imazodan, CI-930, meribendan, bemoradan, senazodan, siguazodan, amipizone, prinoxodan, Y-590, SK&F-93741, SKF 95654, NSP-805, NSP-804 and KF 15232. This study briefly reviews the pyridazinone ring for the progress of new cardio-active drugs.

Multicomponent Enantioselective Synthesis of Tetrahydropyridazinones Employing Chiral α,β-Unsaturated Acylammonium Salts

“…The pyridazinone nucleus is represented in a variety of pharmaceutical agents at various oxidation states, with many utilized to address cardiovascular disease (Figure ). N -Phenyl tetrahydropyridazinone is an orally active 5-lipooxygenase inhibitor . Several 4-aryl-substituted dihydropyridazinones, including bemoradan as a racemate, are used for hypertension .…”

“…Several 4-aryl-substituted dihydropyridazinones, including bemoradan as a racemate, are used for hypertension . Pimobendan is used for heart disease in dogs, acting as an inodilator, a drug that serves as both a vasodilator and a muscle strengthening agent . Other dihydropyridazinones include imazodan and levosimendan, which have utility as treatments for congestive heart failure.…”

“…N-Phenyl tetrahydropyridazinone is an orally active 5-lipooxygenase inhibitor. 26 Several 4-aryl-substituted dihydropyridazinones, including bemoradan as a racemate, are used for hypertension. 27 Pimobendan is used for heart disease in dogs, acting as an inodilator, a drug that serves as both a vasodilator and a muscle strengthening agent.…”

“…27 Pimobendan is used for heart disease in dogs, acting as an inodilator, a drug that serves as both a vasodilator and a muscle strengthening agent. 26 Other dihydropyridazinones include imazodan and levosimendan, which have utility as treatments for congestive heart failure. Finally, emorfazone, containing a fully oxidized aromatic pyridazinone as its core, is an analgesic.…”