A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza, Faisal; Zafar, Hajra; Zhu, Ying; Ren, Yuan; Ullah, Aftab; Khan, Asif; He, Xinyi; Han, Han; Aquib, Md; Boakye‐Yiadom, Kofi Oti; Ge, Liang

doi:10.20944/preprints201710.0178.v1

Cited by 15 publications

(21 citation statements)

References 147 publications

(168 reference statements)

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“…Small peptides have many benefits with respect to large proteins, such as a lack of denaturation, structural stability, ease of synthesis, absence of a need for a secondary conformation to preserve their biological activity, and they tend to be characterized by the absence of immunogenicity and toxicity. [44] [46] There is a noticeable difference between the factor-free ELR and ELR-QK hydrogels.…”

Section: Discussionmentioning

confidence: 99%

Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels

Flora

Torre

Alonso

et al. 2019

J Mater Sci: Mater Med

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Section: Discussionmentioning

confidence: 99%

Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels

Flora

Torre

Alonso

et al. 2019

J Mater Sci: Mater Med

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“…To accomplish these tasks, the GI tract includes a highly acidic environment in the stomach, a significant pH range along the length of the GI tract, and the presence of proteolytic enzymes responsible for protein degradation. These characteristics can interfere with the delivery of fragile biomolecules, such as antigenic proteins or peptides, which are highly susceptible to degradation and denaturation [20]. Furthermore, there is a temporal limitation for the absorption of these formulations due to the residence time in the small intestine (3-4 h), where most absorption processes occur [21].…”

Section: Conventional Vaccines and Their Administrationmentioning

confidence: 99%

Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines

et al. 2019

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Vaccination is considered one of the most successful public health interventions of the modern era. Vaccines are categorized based on the antigen used, delivery system and the route of administration. Traditional vaccines are produced from the dead, attenuated or inactivated pathogens that cause disease. However, newly developed vaccines are DNA based, liposome based, and virus like particle (VLP) based which are more effective and specific to some malignant diseases. The delivery system of vaccines has been advanced along with time as well. New delivery systems such as nanoparticles, liposomes, or cells (for DNA) has been proven to develop a more efficient vaccine. Most vaccines are administered via intramuscular (IM), subcutaneous (SQ) or oral (PO) route. However, these routes of administration have limitations and side effects. An alternative route could be oral cavity administration such as buccal or sublingual administration using film dosage form as delivery vehicle. In this article, we thoroughly reviewed the possibility of developing a quickly soluble film-based delivery system for vaccine administration. We reviewed the different types of new vaccines and vaccine formulations such as VLP based, liposome, bilosome, particulate, and summarized their suitability for use in a film dosage form. Quickly soluble film dosage form is the most optimized form of buccal administration. A film dosage form applied in the buccal cavity has several advantages: they can avoid first pass effect, they are easy to administer and prepare, and they are more cost effective. Since there is no first pass effect, only a small quantity of the vaccine is needed. Vaccines in their original form or in a nano or microparticulate form can be used in a film. The film can also be developed in multilayers to protect the vaccine from degradation by saliva or swallowing. Films are easy to prepare, administer, and can be used for systemic and local action. In addition, most of the current vaccines use mostly the parenteral route of administration, which has some major drawbacks such as poor induction of mucosal immunity, less patient compliant, less potent, high cost and cumbersome production process. Sublingual and buccal vaccine delivery can be good alternatives as they are easier to prepare and safer than parenteral administration routes. The buccal and sublingual administration have the advantage to produce both systemic and mucosal immunity.

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“…The aqueous swellable and crosslinked polymeric network structure of hydrogels was composed of various natural, synthetic and semi-synthetic biodegradable polymers (Raza et al, 2018). The aqueous swellable and crosslinked polymeric network structure of hydrogels was composed of various natural, synthetic and semi-synthetic biodegradable polymers (Raza et al, 2018).…”

Section: Hydrogelsmentioning

confidence: 99%

“…Hydrogels were developed as an excellent carrier for local and controlled drug delivery in clinical medicine. The aqueous swellable and crosslinked polymeric network structure of hydrogels was composed of various natural, synthetic and semi-synthetic biodegradable polymers (Raza et al, 2018). Among developed hydrogels, self-assembling peptide nanofibrous hydrogels were formed by several types of non-covalent interactions among the peptidic building units and were especially interesting due to their biocompatibility, biodegradability, and low toxicity.…”

Section: Hydrogelsmentioning

confidence: 99%

Improvements in chemical carriers of proteins and peptides

Bolhassani

2019

Cell Biology International

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The successful intracellular delivery of biologically active proteins and peptides plays an important role for therapeutic applications. Indeed, protein/peptide delivery could overcome some problems of gene therapy, for example, controlling the expression levels and the integration of transgene into the host cell genome. Thus, protein/peptide drug delivery showed a promising and safe approach for treatment of cancer and infectious diseases. Due to the unique physical and chemical properties of proteins, their production (e.g., isolation, purification & formulation) and delivery represented significant challenges in pharmaceutical studies. Modification in the structural moieties of these protein/peptide drugs could improve their solubility, stability, crystallinity, lipophilicity, enzymatic susceptibility and targetability, and subsequently, therapies and cures against various diseases. Using the structural modification of protein/peptide, their delivery provided overall higher success rates including high specificity, high activity, bioreactivity and safety. Recently, biotechnological and pharmaceutical companies have tried to find novel techniques for the modifications and improve delivery systems/carriers. However, each carrier has its own benefits and drawbacks, and an appropriate carrier is often established by the physicochemical properties of protein or peptide, the ideal route of injection, and clinical characteristics of therapy. In this review, an attempt was made to give an overview on the chemical carriers for proteins and peptides as well as the recent advances in this field.

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A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Cited by 15 publications

References 147 publications

Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels

Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels

Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines

Improvements in chemical carriers of proteins and peptides

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