2014
DOI: 10.4236/oalib.1100603
|View full text |Cite
|
Sign up to set email alerts
|

A Review on Recombinant Tissue Plasminogen Activator: <i>In Vitro</i> Synthesis and Its Use in Treatment of Acute Ischemic Stroke

Abstract: Tissue-type Plasminogen Activator (tPA) is a serine protease produced by endothelial cells. They target plasminogen, an inactive precursor of plasmin and convert the plasminogen into active plasmin, which degrades the fibrin component of thrombus to aid in dissolution of blood clots. Hence tPA is commonly used in treatment of acute Ischemic stroke in the form of recombinant tissue plasminogen activator (rtPA). rtPA is produced using recombinant technology from different types of vectors depending on the quanti… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 31 publications
(20 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?