A review on selenium nanoparticles and their biomedical applications

Karthik, K.K.; Cheriyan, Binoy Varghese; Rajeshkumar, S.; Gopalakrishnan, Meenaloshini

doi:10.1016/j.bmt.2023.12.001

Cited by 36 publications

(2 citation statements)

References 135 publications

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“…The techniques employed for fabricating SeNPs from plant extracts avoid the use of harmful chemicals, utilize readily available and cost-effective precursors, and do not necessitate specific conditions. [6] Moreover, this synthesis method enables precise control of the shape, size, and stability of SeNPs. [7] Because of their significant biocidal properties, capability to protect cells from free radicals, minimal toxicological repercussions, elevated biological efficacy, and advantageous bioavailability, SeNPs are superior when compared to alternative sources of the selenium (Se) element.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Nanocomposites from Chitosan and Squash Synthesized Nano‐Selenium Eradicate Skin Pathogens

Meshref,

Omar,

Moussa

et al. 2024

ChemistrySelect

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Skin health and protection are paramount in the pursuit of well‐being and beauty. In this study, we introduce an innovative approach to develop skin protectant agents by nanocomposites derived from natural sources, involves the synthesis of selenium nanoparticles (SeNPs) using squash plant mucilage (SqM), and their integration with nano chitosan (NCht) to create a stable, antimicrobial and efficacious composite. The interactions between nanomaterials were proved via infra‐red analysis and electron microscopy. The SqM‐biosynthesized SeNPs had 11.47 nm diameter. Different blends were nanocomposited from NCht and SqM/SeNPs; the NC‐2 nanocomposite (with equal ratios from them) had mean diameter of 241.38 nm and negatively charged. The antimicrobial actions of produced nanomaterials/nanocomposites were validated against skin pathogens, Staphylococcus aureus and Candida albicans, using antimicrobial assays and electron microscopy. The most effectual antimicrobial was NC‐2; the loading of it onto cotton textile provided potent antimicrobial fabrics toward both skin pathogens. The innovative biosynthesis of SeNPs using SqM and their nanocompositing with NCht provided pioneering powerful antimicrobial complexes to control skin pathogens, either through direct interaction or by fabricating hygienic antimicrobial textiles.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Nanocomposites from Chitosan and Squash Synthesized Nano‐Selenium Eradicate Skin Pathogens

Meshref,

Omar,

Moussa

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Consequently, they can result in inadequate biomechanical repair and postoperation failure . To address the issue of poor regenerative characteristics, chemical modifications, such as mRNA, nanomolecular medicines, and various active components such as liposomes are introduced into the biological scaffold. − Nevertheless, due to challenges such as biosafety, packaging efficiency, and difficulties in clinical application, chemical modification is not the most effective way to achieve reliable tendon regeneration.…”

mentioning

confidence: 99%

Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration

Yang,

Xu,

et al. 2024

Nano Lett.

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Inspired by the imbalance between extrinsic and intrinsic tendon healing, this study fabricated a new biofilter scaffold with a hierarchical structure based on a melt electrowriting technique. The outer multilayered fibrous structure with connected porous characteristics provides a novel passageway for vascularization and isolates the penetration of scar fibers, which can be referred to as a biofilter process. In vitro experiments found that the porous architecture in the outer layer can effectively prevent cell infiltration, whereas the aligned fibers in the inner layer can promote cell recruitment and growth, as well as the expression of tendon-associated proteins in a simulated friction condition. It was shown in vivo that the biofilter process could promote tendon healing and reduce scar invasion. Herein, this novel strategy indicates great potential to design new biomaterials for balancing extrinsic and intrinsic healing and realizing scarless tendon healing.

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Mesoporous Biosilica Beads for Controlled Selenium Nanoparticle Delivery from Collagen‐Chitosan Scaffolds: Promoting Bone Formation and Suppressing Prostate Cancer Growth

Kaur,

Falgous,

Kamal

et al. 2024

Advanced NanoBiomed Research

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The controlled delivery of selenium nanoparticles (Se‐NPs) is promising for bone cancer treatment due to their dual benefits in bone regeneration and tumor inhibition, yet achieving an optimal dosing regimen remains challenging. Natural mesoporous biosilica (BS) beads have shown promise for drug delivery due to their microporous structure. This study explores incorporating BS beads into collagen‐chitosan (Coll‐CS) scaffolds, known for bone repair, to control Se‐NP delivery. Two approaches are compared: loading Se‐NPs into BS beads before integrating them into Coll‐CS scaffolds versus directly loading Se‐NPs into Coll‐CS scaffolds. The scaffold properties, Se release kinetics, cytocompatibility, and effects on mesenchymal stem cells (MSCs) and prostate cancer cells (LNCaP) are evaluated. BS bead‐loaded scaffolds provide controlled Se‐NP release and enhanced mechanical properties compared to directly loaded scaffolds. Higher Se‐NP concentrations in BS‐loaded scaffolds effectively promote MSC osteogenic differentiation and mineralisation while inhibiting LNCaP cell viability. In contrast, low Se‐NP concentrations not only induce early osteogenic differentiation but also promote cancer cell proliferation, underscoring the need for optimal Se‐NP concentration and release. These findings suggest that BS bead‐loaded Coll‐CS scaffolds are a promising strategy for controlled Se‐NP delivery, addressing the dual challenges of bone formation and cancer recurrence prevention in bone cancer treatment.

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A review on selenium nanoparticles and their biomedical applications

Cited by 36 publications

References 135 publications

Antimicrobial Nanocomposites from Chitosan and Squash Synthesized Nano‐Selenium Eradicate Skin Pathogens

Antimicrobial Nanocomposites from Chitosan and Squash Synthesized Nano‐Selenium Eradicate Skin Pathogens

Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration

Mesoporous Biosilica Beads for Controlled Selenium Nanoparticle Delivery from Collagen‐Chitosan Scaffolds: Promoting Bone Formation and Suppressing Prostate Cancer Growth

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