A review on the antagonist Ebola: A prophylactic approach

Abstract

Ebola virus (EBOV), a member of Filoviridae virus family under the genus Ebolavirus, has emerged as a dangerous and potential threat to human health globally. It causes a severe and deadly hemorrhagic fever in humans and other mammals, called Ebola Virus Disease (EVD). In recent outbreaks of EVD, there has been loss of large numbers of individual's life. Therefore, EBOV has attracted researchers and increased interests in developing new models for virus evolution, and therapies. The EBOV interacts with the immune system of the host which led to understand how the virus functions and effects immune system behaviour. This article presents an exhaustive review on Ebola research which includes EVD illness, symptoms, transmission patterns, patho-physiology conditions, development of antiviral agents and vaccines, resilient health system, dynamics and mathematical model of EBOV, challenges and prospects for future studies.

Health System Resilience: What Are We Talking About? A Scoping Review Mapping Characteristics and Keywords

“…One source described the meaning of a shock, 19 while the other 8 sources gave examples of what could cause shocks and how they should be addressed. 4,21,[27][28][29][30][31][32] Commonly used examples of a shock were pandemics such as Ebola 31,[33][34][35] or natural disasters. 26,36 Five recurring terms that referred to the capacities or actions that a system could take to be resilient when exposed to a shock were identified in the descriptions of resilience in the literature, namely, adapt, maintain, absorb, respond and transform.…”

“…40 Health Workforce Five articles discussed the need for a workforce with a mix of skills that can adjust to both long-term changes and shocks. 19,34,35,40,42 The competence within the health workforce should be sufficiently high to maintain the daily functions of the health system and still provide quality care, even when resources may be scarce. 19,21,40 The availability of additional workforce resources was raised as a method to improve the speed and effectiveness of the response to a shock while minimizing the negative impact on the system.…”

“…shocks in order to guide plans for improved response. 19,21,34 Leadership and Governance The building block of leadership and governance was mentioned by 20 sources. Accountability and transparency 21,40,43 together with equity 43,44 were emphasized as important responsibilities.…”

“…Six articles stated that a system needs the capacity to predict future challenges to effectively respond and to adjust the system when needed. 20,21,27,34,40,45 This capacity should be built during stable times and not during shocks when the health system is strained and needs to focus on response. 4,8,21,27,32,38 Three articles underscored that new strategies should be developed based on previous experiences and lessons learned should be efficiently implemented.…”

A Coadunation of Biological and Mathematical Perspectives on the Pandemic COVID-19: A Review

“…Since March, 2020, many drug candidates have been subjected tor clinical trials for their development of vaccines and treatments. These drugs mainly include compounds that are used to treat flu, malaria, Ebola disease (Khan et al, 2017). Table 1 summarises the conventional drug leads which have been subjected to clinical trials for COVID-19.…”