Hancang River is a river on the eastern border of Jinan City. In recent years, with the development of cities, river flow has dropped sharply, river water has been polluted, and the ecological environment of the basin has declined. Improving the water ecological environment and enhancing the resilience of the water ecology of the river basin were set as the research goals, especially coupling of hydrological and ecological processes and the recycling of sewage resources. The "patch-corridor-matrix" theory of landscape ecology, the Least-cost distance model and the Arc Hydro Tools module of the ArcGIS platform were used to describe the river system and basin boundaries, optimize the current water network and the path network of the ecosystem. A novel ecological network and water network were proposed to form the final aquatic ecosystem, which combines the hydrological process with the ecosystem, and three decentralized wastewater treatment systems were designed to reduce the wastewater directly flowing into the river. The ecosystem resilience of the basin will be enhanced.