A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

Abstract

Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in the field of tissue regeneration and transplantation for disease treatments. Globally, medicinal plants are being used for the treatment and prevention of a variety of diseases. Phytochemicals like naringin, icariin, genistein, and resveratrol obtained from plants have been extensively used in traditional medicine for centuries. Certain bioactive compounds from plants increase the rate of tissue regeneration, differentiation, and immunomodulation. Several studies show that bioactive compounds from plants have a specific role (bioactive mediator) in regulating the rate of cell division and differentiation through complex signal pathways like BMP2, Runx2, and Wnt. The use of plant bioactive phytochemicals may also become promising in treating diseases like osteoporosis, neurodegenerative disorders, and other tissue degenerative disorders. Thus, the present review article is aimed at highlighting the roles and consequences of plant extracts on MSCs proliferation and desired lineage differentiations.

Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products

“…Literature data indicate that various compounds of plant origin have a different effect on cell proliferation, hence the content of individual compounds and interactions between them will strictly affect the final effect of the extracts 76 . Also, the concentration of individual compounds in the obtained extracts is of great importance for the effect of their action on cells, as numerous studies indicate a dose-dependent effect of compounds of plant origin 77 . The anthocyanins and anthocyanidins contained in the tested plants can also affect cell viability, because, as shown by studies by Wang et al, in low concentrations these compounds can cause arrest in the G0/G1 phase of the cell cycle, while at higher concentrations the cycle is inhibited in phase G2/M.…”

Chlorella vulgaris Extract as a Serum Replacement That Enhances Mammalian Cell Growth and Protein Expression

“…This gives confidence to the use of CGF in cell expansion designated for TERM applications. Given prior studies have shown that plant extracts are capable of stimulating differentiation in MSC, it is important to conduct future complementary investigations to understand the effect of CGF on the differentiation potential of 3D-cultuired ADSC (Zhang et al, 2015;Imran et al, 2017;Saud et al, 2019).…”

Global Gene Expression Profiling Reveals Isorhamnetin Induces Hepatic-Lineage Specific Differentiation in Human Amniotic Epithelial Cells

“…In this context, a new research stream has been evolving to use medicinal plant extracts as stimulants of stem cells because of their high availability, low toxicity, and minimum side effects (Udalamaththa et al, 2016;Kornicka et al, 2017;Udagama and Udalamaththa, 2018;Saud et al, 2019). However, despite the fact that hAECs were discovered decades ago, few researches have been done on using natural compounds to optimize the microenvironment or to regulate the early biological events for controlled differentiation of hAECs.…”