A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance

Abubakar, Ibrahim Babangida; Malami, Ibrahim; Yahaya, Yakubu; Sule, Sahabi Manga

doi:10.1016/j.jep.2018.05.027

Cited by 97 publications

(52 citation statements)

References 130 publications

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“…Galangin is a fl avonoid compound that is commonly used in traditional medicine (24). Many bioactivities of galangin such as: antiinfl ammatory, anticancer, and antiviral effects have been reported (25). In addition, based on the studies reporting the potent acetylcholinesterase inhibitory effect of galangin, it was suggested that galangin might be a potential treatment option in Alzheimer's disease and other dementias (17,23,26,27).…”

Section: Discussionmentioning

confidence: 99%

The effects and mechanisms of the action of galangin on spatial memory in rats

Kılıç¹,

Kaygisiz²,

Aydin³

et al. 2019

BLL

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BACKGROUND: Galangin, a fl avonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission. OBJECTIVES: We aimed to investigate the effects of galangin on spatial memory impairment in rats. METHODS: The effects of galangin (50 and 100 mg/kg) and reference anti-dementia drug donepezil (1mg/ kg) administrations were examined on memory impairment induced by the muscarinic cholinergic receptor antagonist scopolamine or the nicotinic cholinergic receptor antagonist mecamylamine in the Morris water maze (MWM) test. Hippocampal acetylcholine concentrations were also determined. RESULTS: Galangin 50 and 100 mg/kg signifi cantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in scopolamine-treated rats. Galangin 100 mg/kg signifi cantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in mecamylamine-treated rats. The effects of galangin in the MWM were comparable with donepezil. Scopolamine and mecamylamine decreased acetylcholine concentrations, whereas galangin both alone and with mecamylamine or scopolamine administration increased acetylcholine concentrations. CONCLUSION: Galangin improved memory impairment comparable to donepezil and nicotinic and muscarinic receptors may be involved in this effect. Galangin may be considered as a promising fl avonoid in the prevention and treatment of memory impairment in Alzheimer's disease and other dementias (Fig. 7, Ref. 37).

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Section: Discussionmentioning

confidence: 99%

The effects and mechanisms of the action of galangin on spatial memory in rats

Kılıç¹,

Kaygisiz²,

Aydin³

et al. 2019

BLL

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“…Galangal species belong to the family Zingiberaceae, a valuable plant family comprising of several important medicinal plants such as ginger and turmeric (Abubakar et al, 2018). In TPM, the plant is known to have nephroprotective properties and lung tonic activity and is used for the treatment of cough.…”

Section: Clove (Syzygium Aromaticum (L) Merr and Lmperry)mentioning

confidence: 99%

“…In TPM, the plant is known to have nephroprotective properties and lung tonic activity and is used for the treatment of cough. Aside from the essential oil, the most important secondary metabolites in this plant family are diarylheptanoids with significant antiinflammatory properties (Abubakar et al, 2018).…”

Section: Clove (Syzygium Aromaticum (L) Merr and Lmperry)mentioning

confidence: 99%

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Bahramsoltani

Rahimi

2020

Front. Pharmacol.

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A new coronavirus causing severe acute respiratory syndrome (SARS-CoV-2) has emerged and with it, a global investigation of new antiviral treatments and supportive care for organ failure due to this life-threatening viral infection. Traditional Persian Medicine (TPM) is one of the most ancient medical doctrines mostly known with the manuscripts of Avicenna and Rhazes. In this paper, we first introduce a series of medicinal plants that would potentially be beneficial in treating SARS-CoV-2 infection according to TPM textbooks. Then, we review medicinal plants based on the pharmacological studies obtained from electronic databases and discuss their mechanism of action in SARS-CoV-2 infection. There are several medicinal plants in TPM with cardiotonic, kidney tonic, and pulmonary tonic activities, protecting the lung, heart, and kidney, the three main vulnerable organs in SARS-CoV-2 infection. Some medicinal plants can prevent “humor infection”, a situation described in TPM which has similar features to SARS-CoV-2 infection. Pharmacological evaluations are in line with the therapeutic activities of several plants mentioned in TPM, mostly through antiviral, cytoprotective, anti-inflammatory, antioxidant, and anti-apoptotic mechanisms. Amongst the primarily-introduced medicinal plants from TPM, rhubarb, licorice, garlic, saffron, galangal, and clove are the most studied plants and represent candidates for clinical studies. The antiviral compounds isolated from these plants provide novel molecular structures to design new semisynthetic antiviral agents. Future clinical studies in healthy volunteers as well as patients suffering from pulmonary infections are necessary to confirm the safety and efficacy of these plants as complementary and integrative interventions in SARS-CoV-2 infection.

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“…The Alpinia species are one of the Zingiberaceae family species that have been noticed for a long time because of their medicinal and nonmedicinal uses. Many studies turned their attention to these species over the years, most notably Alpinia officinarum Hance (smaller galangal) due to their phytochemistry and pharmacological potency (Abubakar et al., 2018). For more than ten centuries, Alpinia officinarum Hance (ALP) has been used for sexual dysfunction in Persian traditional medicine (Rezaeizadeh et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

et al. 2021

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Nonylphenol (NP), an endocrine‐disrupting chemical, interferes with reproductive function and induces oxidative stress in different organs, including the testis and prostate. Alpinia officinarum Hance (ALP), a plant species of the Zingiberaceae family, has proven antioxidant properties. This study aimed to evaluate the effect of the alcoholic extract of ALP treatment on NP‐induced reproductive toxicity and oxidative stress in male rats using biochemical and histopathological biomarkers. Our experimental groups were defined as follows: oil treatment (control), NP 10 mg/kg, ALP 10 mg/kg (ALP HD), NP + ALP 5 mg/kg (NP + ALP LD) and NP + ALP 10 mg/kg (NP + ALP HD). NP administration caused significant cytotoxicity and a significant increase in oxidative stress prostate‐specific antigen (PSA) levels accompanied by a significant reduction in testosterone levels. The relative weight of the testis of both NP + ALP LD and NP + ALP HD groups was significantly decreased compared to the control group. Histopathological evaluations revealed destructive effects in testis and prostate tissue samples. In conclusion, ALP administration improved cytotoxicity, oxidative stress, testosterone and PSA levels, and testis and prostate tissue destructive effects induced by the NP in male rats.

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A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance

Cited by 97 publications

References 130 publications

The effects and mechanisms of the action of galangin on spatial memory in rats

The effects and mechanisms of the action of galangin on spatial memory in rats

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

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