A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Yu, Sheng; Yan, Hui; Zhang, Li; Shan, Mingqiu; Chen, Peidong; Ding, Anwei; Li, Sam Fong Yau

doi:10.3390/molecules22020299

Cited by 160 publications

(123 citation statements)

References 138 publications

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“…Earlier report suggest diverse pharmacological activities of Amentoflavone. 16 The therapeutic effect on cardiovascular and central nervous system was also reported in earlier studies. [17][18][19] Alphasynuclein is the characteristic property of Parkinson's disease; hence, it has an important application in the clinical diagnosis and therapeutics of Parkinson's disease.…”

Section: Discussionsupporting

confidence: 57%

Molecular Docking Study to Identify Potent Inhibitors of Alpha-synuclein Aggregation of Parkinson’s Disease

Gupta¹,

Gupta²,

Kumar³

et al. 2019

IJCMR

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Introduction: Parkinson's disease (PD) is the widespread neurodegenerative disorder ranked second in this categories and PD is also the most common movement disorder. PD disorder affects more than 0.1% of the total population older than 40 years of age. Contemporary, therapies of PD are restricted to only symptomatic relief without dealing with the basic disease etiology such as aggregation of αSyn, thus the progression of the disease continues with the current therapies. The major objective of this study was to find out putative inhibitors of human alfa-synuclein to search possible therapeutics of Parkinson's disease. Material and Methods: Our study included Molecular docking study of 3D-Structure of alfa-synuclein of human retrieved from PDB with their chemical ligands. The proteinligands docking were performed using AutoDock4.2.5.1. Further, Molecular Dynamic Simulation for protein-ligand complex of best dock complex was carried out using Gromacs16.10. Result: Total nineteen molecules was selected for docking study out of which Amento flavones molecule shows best binding. The molecular docking simulation results indicate that the protein complexes were stable throughout MD simulations and thus proteins possess the ability to stability. Conclusion: This study provides an insight of in-silico drug designing approach towards alfa-synuclein modulators as a promising therapeutics of Parkinson's's disease.

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Section: Discussionsupporting

confidence: 57%

Molecular Docking Study to Identify Potent Inhibitors of Alpha-synuclein Aggregation of Parkinson’s Disease

Gupta¹,

Gupta²,

Kumar³

et al. 2019

IJCMR

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“…In recent years, iridoids have been proven to have a wide range of biological activities, and their pharmacokinetic characteristics have also been widely studied [112]. The different structures of parent nuclei of iridoids result in different metabolic pathways, mainly through the hydrolysis of β-glucosidase, glucose-aldeacidification, isomerization, and other metabolic processes throughout the body [8].…”

Section: Pharmacokinetic Of Iridoidsmentioning

confidence: 99%

Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

et al. 2020

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Iridoids are a class of active compounds that widely exist in the plant kingdom. In recent years, with advances in phytochemical research, many compounds with novel structure and outstanding activity have been identified. Iridoid compounds have been confirmed to mainly exist as the prototype and aglycone and Ι and II metabolites, by biological transformation. These metabolites have been shown to have neuroprotective, hepatoprotective, anti-inflammatory, antitumor, hypoglycemic, and hypolipidemic activities. This review summarizes the new structures and activities of iridoids identified locally and globally, and explains their pharmacokinetics from the aspects of absorption, distribution, metabolism, and excretion according to the differences in their structures, thus providing a theoretical basis for further rational development and utilization of iridoids and their metabolites.

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“…Amentoflavone ( Figure 1A) is a common biflavonoid isolated from a variety of traditional Chinese medicines, such as Selaginella tamariscina or Ginkgo biloba (Yu et al, 2017). Previous studies have indicated that amentoflavone has multiple pharmacological effects, including anti-inflammatory (Zhang et al, 2015), antioxidant (Saroni Arwa et al, 2015), antivirus (Li et al, 2019), and antitumor activities (Lee et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Amentoflavone Attenuates Clostridium perfringens Gas Gangrene by Targeting Alpha-Toxin and Perfringolysin O

et al. 2020

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Clostridium perfringens (C. perfringens) type A strains are the main cause of gas gangrene in humans and animals. Treatment of this lethal disease is limited, and the prognosis is not good. Alpha-toxin (CPA) and perfringolysin O (PFO) secreted by C. perfringens play irreplaceable roles in cytotoxicity to host cells, persistence in host tissues, and lethality of gas gangrene pathology. This work determined the influence of amentoflavone, a biflavonoid isolated from Selaginella tamariscina and other plants, on hemolysis and cytotoxicity mediated by CPA and PFO and evaluated the in vivo therapeutic effect on gas gangrene. Our data showed that amentoflavone could block the hemolysis and cytotoxicity induced by CPA and PFO in vitro, thereby mediating significant protection against mortality of infected mice in a mouse gas gangrene model, efficient bacterial clearance in tissues and alleviation of histological damage in vivo. Based on the above results, amentoflavone may be a potential candidate against C. perfringens infection by reducing CPA and PFO-mediated virulence.

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A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Cited by 160 publications

References 138 publications

Molecular Docking Study to Identify Potent Inhibitors of Alpha-synuclein Aggregation of Parkinson’s Disease

Molecular Docking Study to Identify Potent Inhibitors of Alpha-synuclein Aggregation of Parkinson’s Disease

Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

Amentoflavone Attenuates Clostridium perfringens Gas Gangrene by Targeting Alpha-Toxin and Perfringolysin O

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