A Review on the Potential Benefits of Phosphodiesterase Inhibitors in Various Models of Toxicities in Animals

Ghiasi, Sima; Ghiasi, Sindokht; Abdollahi, Mohammad

doi:10.3923/ajava.2012.210.224

Asian J. of Animal and Veterinary Advances

2012

DOI: 10.3923/ajava.2012.210.224

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A Review on the Potential Benefits of Phosphodiesterase Inhibitors in Various Models of Toxicities in Animals

Sima Ghiasi¹,

Sindokht Ghiasi²,

Mohammad Abdollahi³

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Cited by 3 publications

References 65 publications

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ADMET considerations for phosphodiesterase-5 inhibitors

Rezvanfar¹,

Rahimi²,

Abdollahi³

2012

Expert Opinion on Drug Metabolism & Toxicology

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The authors believe that the enhancing effect of PDE5Is on the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway means that PDE5Is could be used to treat various conditions. An important issue in their development is 'cross-talk' between PDE5 and other PDEs and thus their specificity for other PDEs. But while it might be difficult to achieve the ideal ADMET profile, it should not necessarily prevent further development of a lead PDE5I. The risk assessment of PDE5Is, with respect to their ADMET properties, is therefore very important for predicting drug-drug interactions, possible side effects, ADRs and its future clinical applications.

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ADMET considerations for phosphodiesterase-5 inhibitors

Rezvanfar¹,

Rahimi²,

Abdollahi³

2012

Expert Opinion on Drug Metabolism & Toxicology

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New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders

Safavi¹,

Baeeri²,

Abdollahi³

2013

Expert Opinion on Drug Discovery

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There are only a few selective PDE7 inhibitors that can discriminate between PDE7A and PDE7B, but due to different tissue distribution and physiological functions in the body, the hope is to develop selective PDE7A and PDE7B inhibitors to target more specific functions and pathological conditions without a high likelihood of causing nonspecific side effects. Conventional approaches such as synthesis and QSARs are currently used to find specific PDE7 inhibitors. The development of computational-based screening of databases has provided many opportunities to discover new ligands based on biological activity in a very short period.

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A Review on the Role of Oxidative Stress and Inflammation in Necrotizing Enterocolitis and Benefits of the Phosphodiesterase Inhibitor Pentoxifylline

Mozaffari¹,

Abdollahi²

2013

International J. of Pharmacology

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A Review on the Potential Benefits of Phosphodiesterase Inhibitors in Various Models of Toxicities in Animals

Cited by 3 publications

References 65 publications

ADMET considerations for phosphodiesterase-5 inhibitors

ADMET considerations for phosphodiesterase-5 inhibitors

New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders

A Review on the Role of Oxidative Stress and Inflammation in Necrotizing Enterocolitis and Benefits of the Phosphodiesterase Inhibitor Pentoxifylline

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