A review on the role of PCGEM1 lncRNA in cancer

Ghafouri‐Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Baniahmad, Aria; Taheri, Mohammad; Mokhtari, Majid

doi:10.1016/j.prp.2022.154223

Cited by 1 publication

(1 citation statement)

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“…Prostate Cancer Gene Expression Marker 1 (PCGEM1) has been identified and patented as a regulator of prostate cancer progression ( Ifere and Ananaba, 2009 ). Moreover, research has demonstrated a strong association between PCGEM1 and the advancement of cervical, endometrial, gastric, ovarian, hepatocellular, and renal cancers ( Ghafouri-Fard et al, 2022b ). Baicalein, a monomer extracted from Scutellaria baicalensis, has been linked to tumor cell proliferation, invasion, and metastasis in adenocarcinoma, bladder cancer, breast cancer, and various other cell lines ( Morshed et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Critical roles of lncRNA-mediated autophagy in urologic malignancies

Gan,

Zheng,

Zou

et al. 2024

Front. Pharmacol.

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Urologic oncology is a significant public health concern on a global scale. Recent research indicates that long chain non-coding RNAs (lncRNAs) and autophagy play crucial roles in various cancers, including urologic malignancies. This article provides a summary of the latest research findings, suggesting that lncRNA-mediated autophagy could either suppress or promote tumors in prostate, kidney, and bladder cancers. The intricate network involving different lncRNAs, target genes, and mediated signaling pathways plays a crucial role in urological malignancies by modulating the autophagic process. Dysregulated expression of lncRNAs can disrupt autophagy, leading to tumorigenesis, progression, and enhanced resistance to therapy. Consequently, targeting particular lncRNAs that control autophagy could serve as a dependable diagnostic tool and a promising prognostic biomarker in urologic oncology, while also holding potential as an effective therapeutic approach.

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Section: Introductionmentioning

confidence: 99%