A review on the role of PTENP1 in human disorders with an especial focus on tumor suppressor role of this lncRNA

Ghafouri‐Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Taheri, Mohammad; Dilmaghani, Nader Akbari

doi:10.1186/s12935-022-02625-8

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…PTENP1, the pseudogene of PTEN, is a novel modulator of PTEN expression [140]. The relative expression of PTEN and PTENP1 change according to the variable stages and histological grades of different tumors [141][142][143]. Prostate cancer associated transcript-1(PCAT-1) is an oncogenic lncRNA, high expression of PCAT-1 is associated with poor overall survival of cancer.…”

Section: Discussionmentioning

confidence: 99%

Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

Yang,

Miao,

et al. 2023

J Nanobiotechnol

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Exosomes are lipid bilayer vesicles with a diameter of 40–100 nm secreted by almost all cells. They have been found play crucial regulatory roles in various diseases. With the development of exosomes engineering technology, exosome-based drug delivery has also rapidly evolved. Bladder cancer is a worldwide disease with high morbidity and recurrence but lack of funding, so it is also called Cinderella. Some explorations have demonstrated that exosomes are important in the development, prognosis, diagnosis and drug delivery of bladder cancer. With the rapid development of Mass spectrometry and next-generation sequencing, increasing numbers of differentially expressed molecules derived from exosomes have been found in bladder cancer. Exosomes and their contents are largely involved in bladder cancer progression, engineering of these exosomes with the targeted genes improves their potential for drug delivery of bladder cancer. Furthermore, exosomes and their contents are relate to many characteristics of bladder cancer. Herein, we briefly search 59 researches to explore the cargoes encapsuled in exosomes of bladder cancer patients. We also summarize the biogenesis, function, expression profiles, engineering approaches and biological mechanisms of exosomes and their contents for the diagnosis, prognosis and drug delivery for bladder cancer. We aim to make it clear whether exosomes are the glass slippers of Cinderella. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

Yang,

Miao,

et al. 2023

J Nanobiotechnol

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“…Disruption of the PTEN-miRNA-PTENP1 axis and ceRNA networks in carcinogenic progression is contemporary and is an exciting area in the discovery of regulatory mechanisms that are altered in cancer. In addition to its regulation of PTEN expression, PTENP1 is able to act as a tumour suppressor independent of its PTEN regulatory function as described in a recent review of the role of PTENP1 in human disorders with a focus on its tumour suppressor functionality [20].…”

Section: Introductionmentioning

confidence: 99%

PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics

Travis,

McGowan,

Simpson

et al. 2023

Cancers

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The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a well characterised tumour suppressor, playing a critical role in the maintenance of fundamental cellular processes including cell proliferation, migration, metabolism, and survival. Subtle decreases in cellular levels of PTEN result in the development and progression of cancer, hence there is tight regulation of the expression, activity, and cellular half-life of PTEN at the transcriptional, post-transcriptional, and post-translational levels. PTENP1, the processed pseudogene of PTEN, is an important transcriptional and post-transcriptional regulator of PTEN. PTENP1 expression produces sense and antisense transcripts modulating PTEN expression, in conjunction with miRNAs. Due to the high sequence similarity between PTEN and the PTENP1 sense transcript, the transcripts possess common miRNA binding sites with the potential for PTENP1 to compete for the binding, or ‘sponging’, of miRNAs that would otherwise target the PTEN transcript. PTENP1 therefore acts as a competitive endogenous RNA (ceRNA), competing with PTEN for the binding of specific miRNAs to alter the abundance of PTEN. Transcription from the antisense strand produces two functionally independent isoforms (PTENP1-AS-α and PTENP1-AS-β), which can regulate PTEN transcription. In this review, we provide an overview of the post-transcriptional regulation of PTEN through interaction with its pseudogene, the cellular miRNA milieu and operation of the ceRNA network. Furthermore, its importance in maintaining cellular integrity and how disruption of this PTEN–miRNA–PTENP1 axis may lead to cancer but also provide novel therapeutic opportunities, is discussed. Precision targeting of PTENP1-miRNA mediated regulation of PTEN may present as a viable alternative therapy.

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“…Through interactions with DNA, RNA, and protein molecules, lncRNAs contribute to intricate regulatory networks that are involved in a wide range of cellular processes and pathological functions [8][9][10][11]. Recent evidence continues to accumulate, shedding light on the pivotal roles of lncRNAs as either oncogenes or tumor suppressors, underscoring their potential as therapeutic targets in various disorders, with a particular emphasis on cancer [12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Tumor Suppressor LncRNA on Chromosome 8p12 (TSLNC8): A Concise Review in Human Malignancies

Li,

Huang,

Liu

et al. 2023

J. Cancer

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Tumor Suppressor Long Non-Coding RNA on Chromosome 8p12 (TSLNC8) is an RNA gene that generates a long non-coding RNA transcribed intergenically from both strands. Its significant role in human malignancies attracted significant attention in recent years. Expression analysis of TSLNC8 has been conducted in tissue specimens and cell lines using various techniques, including reverse transcription-quantitative polymerase chain reaction (RT-qPCR), in situ hybridization (ISH), and microarray analysis. Furthermore, functional studies involving the loss and/or gain of TSLNC8 function in cellular and animal models have been carried out. These investigations have highlighted the impact of TSLNC8 on key tumor-related processes, including migration, invasion, and metastasis. Moreover, TSLNC8 has emerged as a regulator capable of modulating critical signaling pathways, such as the Hippo, STAT3, WNT/β-catenin, and MAPK pathways. In this review, we comprehensively synthesize the findings derived from in vitro and in vivo studies, along with analyses conducted on clinical samples, to provide a comprehensive understanding of the multifaceted role of TSLNC8 as a promising tumor biomarker and a potential target for therapeutic interventions.

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A review on the role of PTENP1 in human disorders with an especial focus on tumor suppressor role of this lncRNA

Cited by 8 publications

References 42 publications

Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics

Tumor Suppressor LncRNA on Chromosome 8p12 (TSLNC8): A Concise Review in Human Malignancies

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