A review on the synthesis and properties of hydroxyapatite for biomedical applications

Dileepkumar, V.G.; Sridhar, Mysore Santosh; Aramwit, Pornanong; Крутько, В. К.; Musskaya, O. N.; Глазов, И. Е.; Reddy, Narendra

doi:10.1080/09205063.2021.1980985

Cited by 78 publications

(32 citation statements)

References 130 publications

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“…The TEM measurements ( Figure 2 ) showed the presence of HAp aggregates, consisting of needle-like nanosized individual particles. Those observations were in good agreement with other reports on the microstructure of synthetic HAp [ 56 , 57 , 58 ]. The HAp obtained has a width of ~10 nm and a length between 10−80 nm.…”

Section: Resultssupporting

confidence: 93%

Composite Coatings for Osteoblast Growth Attachment Fabricated by Matrix-Assisted Pulsed Laser Evaporation

et al. 2022

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The bioactive and biocompatible properties of hydroxyapatite (HAp) promote the osseointegration process. HAp is widely used in biomedical applications, especially in orthopedics, as well as a coating material for metallic implants. We obtained composite coatings based on HAp, chitosan (CS), and FGF2 by a matrix-assisted pulsed laser evaporation (MAPLE) technique. The coatings were physico-chemically investigated by means of X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Infrared Microscopy (IRM), and Scanning Electron Microscopy (SEM). Further, biological investigations were performed. The MAPLE-composite coatings were tested in vitro on the MC3T3-E1 cell line in order to endorse cell attachment and growth without toxic effects and to promote pre-osteoblast differentiation towards the osteogenic lineage. These coatings can be considered suitable for bone tissue engineering applications that lack toxicity and promotes cell adhesion and proliferation while also sustaining the differentiation of pre-osteoblasts towards mature bone cells.

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Section: Resultssupporting

confidence: 93%

Composite Coatings for Osteoblast Growth Attachment Fabricated by Matrix-Assisted Pulsed Laser Evaporation

et al. 2022

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“…Particularly in regard to osteoclasts, it has been reported that hydroxyapatite with a particle size of ~500 nm beneficially influences osteoclast formation and function compared to smaller-sized materials [ 7 ]. Thus, considering the controversy of material sizes, it is suggested that the submicron-scale materials potentially have superior action on bone cells, particularly osteoclasts, and may be combined with other ceramics to produce desired characteristics for bone tissue regeneration [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have reported that critical parameters must be considered when fabricating hydroxyapatite [ 13 , 14 , 22 , 23 ]. Due to the high compressive strength property of BHA, an appropriate method should be chosen to reduce the particle size of the BHA.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Submicron-Scale Bovine Hydroxyapatite: A Top-Down Approach for a Natural Biomaterial

et al. 2022

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Submicron hydroxyapatite has been reported to have beneficial effects in bone tissue engineering. This study aimed to fabricate submicron-scale bovine hydroxyapatite (BHA) using the high-energy dry ball milling method. Bovine cortical bone was pretreated and calcined to produce BHA powder scaled in microns. BHA was used to fabricate submicron BHA with milling treatment for 3, 6, and 9 h and was characterized by using dynamic light scattering, scanning electron microscope connected with energy dispersive X-Ray spectroscopy, Fourier-transform infrared spectroscopy, and X-ray diffractometry to obtain its particle size, calcium-to-phosphorus (Ca/P) ratio, functional chemical group, and XRD peaks and crystallinity. Results showed that the particle size of BHA had a wide distribution range, with peaks from ~5 to ~10 µm. Milling treatment for 3, 6, and 9 h successfully gradually reduced the particle size of BHA to a submicron scale. The milled BHA’s hydrodynamic size was significantly smaller compared to unmilled BHA. Milling treatment reduced the crystallinity of BHA. However, the treatment did not affect other characteristics; unmilled and milled BHA was shaped hexagonally, had carbonate and phosphate substitution groups, and the Ca/P ratio ranged from 1.48 to 1.68. In conclusion, the fabrication of submicron-scale BHA was successfully conducted using a high-energy dry ball milling method. The milling treatment did not affect the natural characteristics of BHA. Thus, the submicron-scale BHA may be potentially useful as a biomaterial for bone grafts.

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“…Methods using aqueous or nonaqueous solutions and suspension can be carried out at additional impacts of microwave radiation [17], mechanical activation [18], ultrasound radiation [19], or combustion [20]. The simplest and most common method to obtain hydroxyapatite powder is its precipitation from an aqueous solution of the corresponding substances, which are phosphoric acid or soluble phosphates of ammonium, sodium, potassium as phosphate ion sources and soluble calcium salts (acetate, nitrate, and chloride) as calcium ion sources [21,22]. Another method to prepare HA powders or ceramics comprises heat treatment of preliminarily homogenized powder mixtures of different salts with the preset molar ratio of Ca/P = 1.67 [23].…”

Section: Introductionmentioning

confidence: 99%

Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite

et al. 2022

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Powder mixtures with a given molar ratio of Ca/P = 1.67 were prepared under mechanical activation conditions from hydroxyapatite powder Ca10(PO4)6(OH)2 and a 1M aqueous solution of oxalic acid H2C2O4 at a molar ratio of Ca10(PO4)6(OH)2/H2C2O4 = 1:4. The phase composition of obtained powder mixture included brushite (calcium hydrophosphate dihydrate) CaHPO4·2H2O, calcium oxalate monohydrate CaC2O4·H2O in form of whewellite and weddellite, and some quantity of quasi-amorphous phase. This powder mixture was used to produce microporous monophase ceramics based on hydroxyapatite Ca10(PO4)6(OH)2 with apparent density of 1.25 g/cm3 after firing at 1200 °C. Microporosity of sintered ceramics was formed due to the presence of particles with plate-like morphology, restraining shrinkage during sintering. Microporous ceramics based on hydroxyapatite Ca10(PO4)6(OH)2 with the roughness of the surface as a consequence of the created microporosity can be recommended as a biocompatible material for bone defects treatment and as a substrate for bone cell cultivation.

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A review on the synthesis and properties of hydroxyapatite for biomedical applications

Cited by 78 publications

References 130 publications

Composite Coatings for Osteoblast Growth Attachment Fabricated by Matrix-Assisted Pulsed Laser Evaporation

Composite Coatings for Osteoblast Growth Attachment Fabricated by Matrix-Assisted Pulsed Laser Evaporation

Fabrication and Characterization of Submicron-Scale Bovine Hydroxyapatite: A Top-Down Approach for a Natural Biomaterial

Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite

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