A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates

Özbek, Oğuz; Gürdere, Meliha Burcu

doi:10.1007/s00044-020-02595-4

Cited by 27 publications

(17 citation statements)

References 82 publications

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“…The therapeutic potential of a benzimidazole molecule dates back to 1944 [ 20 ]. The presence of the benzimidazole molecule in bioactive compounds has an impact on antiparasitic, anticonvulsant, analgesic, antihistaminic, antiulcer, antihypertensive, antiviral, anticancer, antifungal and anti-inflammatory agents, and this compound has anticoagulant properties [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In this work, we focused on the design and creation of medically active coordination compounds containing a benzimidazole core, with potential anticancer properties and an element essential for all living organisms—zinc [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Raducka

Świątkowski

Korona-Głowniak

et al. 2022

IJMS

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Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named C1, C2, C4 and C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. The collected analytical data allowed the determination of the stoichiometry in coordination compounds, thermal stability, crystal structure and way of bonding. The cytotoxicity effect of the new compounds as a potential antitumor agent on the glioblastoma (T98G), neuroblastoma (SK-N-AS) and lung adenocarcinoma (A549) cell lines and human normal skin fibroblasts (CCD-1059Sk) was also determined. Cell viability was determined by the MTT assay. The results obtained confirmed that conversion of ligands into the respective metal complexes significantly improved their anticancer properties. The complexes were screened for antibacterial and antifungal activities. The ADME technique was used to determine the physicochemical and biological properties.

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Section: Introductionmentioning

confidence: 99%

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Raducka

Świątkowski

Korona-Głowniak

et al. 2022

IJMS

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“…In the current study, anti-fungal properties of Marrubium vulgare L. extracts in different solvents against certain plant pathogenic fungi were determined. Today, diverse set of organic and inorganic molecules were synthesized in the laboratory conditions using different methodologies, and their multiple biological functions including anti-fungal properties were studied (Özbek et al, 2017;Gürdere et al, 2020;Özbek and Gürdere, 2020). However, in the present study, natural plant-based extracts were analyzed in terms of their antifungal activities.…”

Section: Discussionmentioning

confidence: 98%

The use of Marrubium vulgare L. plant extracts in the control of fungal plant pathogens

Özbek

Budak

Berkel

et al. 2020

International Journal of Agriculture Environment and Food Sciences

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In this study, we investigated anti-fungal properties of Marrubium vulgare L. plant extracts dissolved in four different solvents against five different plant pathogenic fungi, namely, Fusarium oxysporum f. sp. lycopersici, Macrophamina phaseolina, Phytopthora infestans, Sclerotinia sclerotiorum and Rhizoctania solani. We used 1.0%, 2.5% and 5.0% plant extract concentrations against these fungi species which cause a significant decrease in the production yield of certain plants. In all pathogenic fungi species analyzed, we observed an increase in the antifungal effect of Marrubium vulgare L. plant extract preparations in a dose-dependent manner. Marrubium vulgare L. extracts dissolved in chloroform and dichloromethane at 2.5% concentration showed higher inhibition against Fusarium oxysporum compared to other solvents at this concentration. At the same concentration, extracts dissolved in methanol resulted in higher anti-fungal activity against Phytopthora infestans and intermediate activity against Macrophamina phaseolina and Sclerotinia sclerotiorum. As a result, it can be stated that Marrubium vulgare L. plant extracts dissolved in different solvents display anti-fungal properties against certain plant pathogens.

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“…The synthesis and properties of organic compounds with anticonvulsant properties have been reviewed by Özbek and Gürdere (46). The same authors published in Phosphorus, Sulfur and Silicon and Related Elements in 2021 about 2-aminothiazole derivatives for their anticancer properties.…”

Section: Reviews About Similar Moleculesmentioning

confidence: 99%

On the Biological Importance, Preparation, and Uses of Imidazo[1,2-b]pyridazine-Based Compounds

Akkurt

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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While studying several pyridazine compounds, the author discovered imidazo[1,2-b]pyridazine (IMP), which is a very versatile compound class. It has been an inhibitor for many enzymes and also it is used as a brominating reagent in organic syntheses. Owing to its high biological activity, researchers have always considered including this molecule in their final structures. This humble attempt just aims to introduce this very powerful molecule to the readers, primarily of chemical origin, and should not be considered as a full treatise of, especially, the medicinal chemistry of the molecule. This work discusses the inhibitory effects, organic chemistry, applications in material chemistry, and theoretical studies of IMP and related molecules. The readers are hereby encouraged to work with medicinal chemists with the newly prepared molecules including this and similar molecules, in the struggle with many diseases like cancer, Alzheimer’s, and others.

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A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates

Cited by 27 publications

References 82 publications

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

The use of Marrubium vulgare L. plant extracts in the control of fungal plant pathogens

On the Biological Importance, Preparation, and Uses of Imidazo[1,2-b]pyridazine-Based Compounds

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