A review on the toxicity of silver nanoparticles against different biosystems

Rajan, Ramachandran; Huo, Peipei; Krishnaraj, Chandran; Dakshinamoorthi, Balakumaran Manickam; Yun, Soon‐Il; Liu, Bo

doi:10.1016/j.chemosphere.2021.133397

Cited by 34 publications

(15 citation statements)

References 147 publications

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“…Silver nanoparticles were tested on various model organisms, from single-celled organisms to organisms with a developed multiorgan system, against which they showed positive and negative effects in their toxicity [ 95 ]. Innovative approaches are also used to reduce/replace animal studies, such as reliable and predictive new approach methodologies (NAM), based on advanced in vitro methods (cytotoxicity and genotoxicity assays in cell lines) and in silico modelling (e.g., quantitative structure–activity relationships [QSAR]).…”

Section: Toxicological Aspects Of Silver Nanoparticlesmentioning

confidence: 99%

Toxicological Aspects, Safety Assessment, and Green Toxicology of Silver Nanoparticles (AgNPs)—Critical Review: State of the Art

Noga¹,

Milan

Frydrych

et al. 2023

IJMS

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In recent years, research on silver nanoparticles (AgNPs) has attracted considerable interest among scientists because of, among other things, their alternative application to well-known medical agents with antibacterial properties. The size of the silver nanoparticles ranges from 1 to 100 nm. In this paper, we review the progress of research on AgNPs with respect to the synthesis, applications, and toxicological safety of AgNPs, and the issue of in vivo and in vitro research on silver nanoparticles. AgNPs’ synthesis methods include physical, chemical, and biological routes, as well as “green synthesis”. The content of this article covers issues related to the disadvantages of physical and chemical methods, which are expensive and can also have toxicity. This review pays special attention to AgNP biosafety concerns, such as potential toxicity to cells, tissues, and organs.

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Section: Toxicological Aspects Of Silver Nanoparticlesmentioning

confidence: 99%

Toxicological Aspects, Safety Assessment, and Green Toxicology of Silver Nanoparticles (AgNPs)—Critical Review: State of the Art

Noga¹,

Milan

Frydrych

et al. 2023

IJMS

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Section: Metabolomics For the Cytotoxicity Assessment Of Npsmentioning

confidence: 99%

“…184,185 Regarding the use of AgNPs as potential drug carriers for cancer therapy from proteogenomic and metabolomic perspectives, the reader is directed to the review by Raja et al 186 AgNPs have been shown to inuence different cells causing apoptosis, lipid peroxidation, and DNA damage. [187][188][189][190] One of the advantages of metabolomics is that it is capable of detecting early biochemical events and metabolic changes even during the absence of a signicant cytotoxic response by conventional assays. Carrola et al 191 studied the effect of citratestabilized 30 nm AgNPs on the human epidermis keratinocyte (HaCaT) cell line aer 48 h of exposure at two concentrations, i.e., 40 mg mL −1 (close to IC 50 = 38.7 ± 2.5 mg mL −1 ) and 10 mg mL −1 (no signicant cell viability loss).…”

Section: Agnpsmentioning

confidence: 99%

The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

Awashra

Młynarz

2023

Nanoscale Adv.

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“…However, the use of AgNPs raises several concerns, with the foremost being their potential environmental impact. AgNPs can accumulate in soil, posing a threat to nontarget beneficial organisms and aquatic life [ 28 ]. This accumulation has the potential to disrupt the delicate environmental balance and disturb microbial ecosystems [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Suppression of Root Rot Fungal Diseases in Common Beans (Phaseolus vulgaris L.) through the Application of Biologically Synthesized Silver Nanoparticles

Ibrahim,

Ahmad,

Abdo

et al. 2024

Nanomaterials

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The biosynthesis of silver nanoparticles (AgNPs) using plant extracts has become a safe replacement for conventional chemical synthesis methods to fight plant pathogens. In this study, the antifungal activity of biosynthesized AgNPs was evaluated both in vitro and under greenhouse conditions against root rot fungi of common beans (Phaseolus vulgaris L.), including Macrophomina phaseolina, Pythium graminicola, Rhizoctonia solani, and Sclerotium rolfsii. Among the eleven biosynthesized AgNPs, those synthesized using Alhagi graecorum plant extract displayed the highest efficacy in suppressing those fungi. The findings showed that using AgNPs made with A. graecorum at a concentration of 100 μg/mL greatly slowed down the growth of mycelium for R. solani, P. graminicola, S. rolfsii, and M. phaseolina by 92.60%, 94.44%, 75.93%, and 79.63%, respectively. Additionally, the minimum inhibitory concentration (75 μg/mL) of AgNPs synthesized by A. graecorum was very effective against all of these fungi, lowering the pre-emergence damping-off, post-emergence damping-off, and disease percent and severity in vitro and greenhouse conditions. Additionally, the treatment with AgNPs led to increased root length, shoot length, fresh weight, dry weight, and vigor index of bean seedlings compared to the control group. The synthesis of nanoparticles using A. graecorum was confirmed using various physicochemical techniques, including UV spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) analysis. Collectively, the findings of this study highlight the potential of AgNPs as an effective and environmentally sustainable approach for controlling root rot fungi in beans.

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A review on the toxicity of silver nanoparticles against different biosystems

Cited by 34 publications

References 147 publications

Toxicological Aspects, Safety Assessment, and Green Toxicology of Silver Nanoparticles (AgNPs)—Critical Review: State of the Art

Toxicological Aspects, Safety Assessment, and Green Toxicology of Silver Nanoparticles (AgNPs)—Critical Review: State of the Art

The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

Suppression of Root Rot Fungal Diseases in Common Beans (Phaseolus vulgaris L.) through the Application of Biologically Synthesized Silver Nanoparticles

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