A review on traditionally used medicinal plants for scabies therapy in Ethiopia

Nigussie, Gashaw

doi:10.1007/s13596-020-00453-7

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…Beta-blockers, statins, fibrates and glibenclamide are usually known as the most commonly used drugs for patients with metabolic syndrome ( Gharipour et al, 2011 ). However, these drugs are often costly, poorly tolerated by patients, associated with various side effects and do not have sustainable effectiveness ( Nigussie, 2021 ). Additionally, typically represent monotherapy and address only a limited range of health outcomes associated with metabolic disorders ( Tola et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Natural products for managing metabolic syndrome: a scoping review

Abdulghani,

Al-Fayyadh

2024

Front. Pharmacol.

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IntroductionMetabolic syndrome comprises a collection of metabolic disorders stemming from factors like genetic predisposition, inadequate nutrition, stress, decreased physical activity, aging, and ethnicity. Although traditional pharmaceutical treatments exist for metabolic syndrome, their limited popularity is attributed to high costs and adverse effects. Consequently, natural products with fewer side effects have been explored for managing this condition. This literature review aims to explore the role of natural products including herbs, botanicals, vitamins, minerals, probiotics, and dietary supplements in managing metabolic syndrome.MethodsThis scoping review was conducted in five steps, involving the formulation of a research question, the retrieval and extraction of relevant studies, the selection of pertinent studies, the organization of information into tables, and the reporting of results. Data was collected from various databases including Embase, Science Direct, PubMed, Google Scholar, Scopus, and Web of Science, with a focus on studies published from 2010 to the present, available in English and with full-text accessibility.ResultsWe identified 1,259 articles, screened their titles, abstracts, and full texts, ultimately incorporating 169 pertinent articles into this review (comprising 90 review articles, 32 trial articles, 6 in vitro articles, 38 in vivo articles, 1 experimental article and 2 observational articles). The study’s outcomes revealed that natural products, encompassing plants and their derivatives, vitamins and supplements, as well as probiotics, can exert a beneficial influence on metabolic syndrome by regulating blood sugar, blood pressure, lipid profiles, obesity, and abnormal cholesterol and triglyceride levels.ConclusionThe current study underscores the significance of natural products in addressing metabolic syndrome. Consequently, it is advisable to conduct further extensive research to assess the efficacy of these products, potentially integrating them into treatment regimens for individuals with metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

Natural products for managing metabolic syndrome: a scoping review

Abdulghani,

Al-Fayyadh

2024

Front. Pharmacol.

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“…Herbal remedies should be used in these alternate MetS risk factor management strategies. Medicinal plants are defined as any plant or plant preparation that has beneficial therapeutic and/or preventive properties or that provides health-promoting properties and temporary relief [ 7 ]. Medicinal plants are now accepted by healthcare providers as having a role to play in the management and prevention of metabolic disorders [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Tola

Ibrahim

Melak

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. MetS are common throughout the world, including Ethiopia. These have traditionally been treated using medicinal plants, particularly in rural areas where they are freely accessible. This systematic review tried to investigate the treatment of MetS with Ethiopian medicinal herbs and made recommendations for more validation research. A careful analysis of the literature was also conducted on the therapeutic effects of these and other Ethiopian medicinal plants with hepatoprotective and antihypertensive activities. Methods. The relevant keywords “Ethnomedicinal + hypertension,” “Ethnopharmacological + hypertension,” “Ethnomedicinal + hepatitis, jaundices, and liver disease,” “Ethnopharmacological + hepatic disorder,” and “Ethnomedicinal + weight loss” were used to search for relevant articles in the major electronic scientific databases, including PubMed, Science Direct, Web of Science, and Google Scholar. The search strategy included all articles with descriptions that were accessible until April 30, 2022. The study’s subjects, methods, or year of publication were no restrictions in the search. The outcomes were compiled using descriptive statistics. Results. Fifty-four (54) studies were examined in the review that satisfied the inclusion and exclusion criteria for the treatment of MetS in Ethiopia. The most often used ethnobotanical plant species for the treatment of hypertension and hepatic disorders were Moringa stenopetala and Croton macrostachyus. Both hepatic and hypertensive disorders were treated more frequently with leaves (52% and 39%, respectively) than with roots (20% and 13%, respectively). Some intriguing studies came from an ethnobotanical investigation into medicinal herbs’ hepatoprotective and antihypertensive properties. The most often investigated medicinal plant for its antihypertensive effects is Moringa stenopetala. Conclusion. The study revealed that Ethiopians often use anti-MetS herbal remedies. We advocate the experimental validation of the commonly used medicinal plants with the identification of active compounds and the development of effective alternative drugs for the treatment of MetS.

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“…One approach to the development of novel anti-malarial drugs is to reinvestigate traditional medicines. In this context, Ethiopia possesses a diverse range of medicinal plants linked to a variety of traditional medical practices that vary by ethnic group [ 15 ]. Despite this, there is a paucity of well-documented ethnobotanical and ethnopharmacological literature on Ethiopian anti-malarial herbs.…”

Section: Introductionmentioning

confidence: 99%

Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies

Nigussie

Wale

2022

Malar J

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Background Malaria is extremely common in Ethiopia, and it is one of the country's most serious public health and economic problems. Traditional medicines have long been utilized in Ethiopia by people of various ethnic groups. As a result, the goal of this study is to record the use of Ethiopian medicinal herbs that have been used to treat malaria. Also, a critical review of the literature on the therapeutic properties of these and other Ethiopian medicinal plants that have been tested against Plasmodium spp. parasites was conducted with the goal of highlighting neglected studies and fostering further research in this area. Methods A comprehensive literature search was performed in Scopus, Web of Science Core Collection, PubMed, Science Direct, Google Scholar, and Scientific Electronic Library Online (SciELO) from August 2021 to October 2021. The study databases included original articles published in peer reviewed journals covering anti-malarial plants, dated until October 2021. Results The review looked at 51 plant species (28 families) that have been used to treat malaria in Ethiopia. The most often used ethnobotanical plant species for the treatment of malaria were Allium sativum, Croton macrostachyus, Carica papaya, and Lepidium sativum. Leaves were used more frequently as a therapeutic preparation than other parts. Plant extracts were found to have very good, good, and moderate anti-malarial activity in mice with rodent Plasmodium species. The most active species were Ajuga remota and Capsicum frufescens, which suppressed parasitaemia by 77.34% and 72.65%, respectively, at an oral dose of 100 mg/kg and an LD50 of above 2000 mg/kg. The compound Aloinoside reported from Aloe macrocarpa leave latex was the most potent; it suppressed parasitaemia by 100% at 400 mg/kg oral dose of Plasmodium berghei infected mice, and its LD50 was above 2000 mg/kg. Toxicity was shown to be safe in 84% of the plant extracts. Conclusion In Ethiopia, medicinal plants have a significant part in reducing the severity of malaria due to their widespread use. As a result, more studies are needed to identify and develop effective novel drugs that could be employed in broader malaria eradication efforts.

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A review on traditionally used medicinal plants for scabies therapy in Ethiopia

Cited by 9 publications

References 39 publications

Natural products for managing metabolic syndrome: a scoping review

Natural products for managing metabolic syndrome: a scoping review

Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies

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