A right ventricular diastolic impairment is common in systemic sclerosis and is associated with other target-organ damage

Meune, Christophe; Khanna, Dinesh; Aboulhosn, Jamil; Avouac, Jérôme; Kahan, André; Fürst, Daniel E.; Allanore, Yannick

doi:10.1016/j.semarthrit.2015.07.002

Cited by 29 publications

(26 citation statements)

References 33 publications

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Section: Discussionmentioning

confidence: 77%

“…Their authors agreed about the negative effect of SSc on RV diastolic function assessed by Doppler imaging . On the other hand, changes in RV systolic function evaluated by different 2DE parameters were reported by some investigators, but not by others …”

Section: Discussionmentioning

confidence: 89%

“…Previous studies that investigated RV remodeling showed that RV systolic and diastolic function are significantly deteriorated in the SSc population . Their authors agreed about the negative effect of SSc on RV diastolic function assessed by Doppler imaging . On the other hand, changes in RV systolic function evaluated by different 2DE parameters were reported by some investigators, but not by others …”

Section: Discussionmentioning

confidence: 91%

“…However, arrhythmias, conduction disturbances, myocardial fibrosis, and ischemia have been shown to be associated with worse outcome in these patients . In the last two decades, SSc has been shown to lead to cardiac remodeling and to deteriorate all cardiac chambers . New imaging techniques like speckle tracking imaging and three‐dimensional echocardiography offered an insight into cardiac function and mechanics in the SSc patients comparable with that of cardiac magnetic resonance, the “gold standard” cardiac imaging modality .…”

Section: Introductionmentioning

confidence: 99%

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Systemic sclerosis impacts right heart and cardiac autonomic nervous system

Tadić

Zlatanović²,

Cuspidi

et al. 2017

J of Clinical Ultrasound

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Systemic sclerosis impacts right heart and cardiac autonomic nervous system

Tadić

Zlatanović²,

Cuspidi

et al. 2017

J of Clinical Ultrasound

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“…The right ventricle (RV) is vulnerable to increased afterload, a common feature of pulmonary affection in SSc. Reported frequencies of RV systolic dysfunction in SSc ranges from 4%‐38%, depending on the applied method Patients, irrespective of pulmonary pressures, seem to present lower values of RV systolic parameters than controls . Tricuspid annular plane systolic excursion (TAPSE) is a leading echocardiographic parameter of RV systolic function, and SSc patients have been shown to present lower values of TAPSE compared with healthy controls .…”

Section: Introductionmentioning

confidence: 99%

Systolic Dysfunction in Systemic Sclerosis: Prevalence and Prognostic Implications

Tennøe

Murbræch

Andreassen

et al. 2019

ACR Open Rheumatology

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Objective. Primary cardiac involvement is presumed to account for a substantial part of disease-related mortality in systemic sclerosis (SSc). Still, there are knowledge gaps on the evolution and total burden of systolic dysfunction in SSc. Here we evaluated prospective left ventricular (LV) and right ventricular (RV) systolic function in an unselected SSc cohort and assessed the burden of systolic dysfunction on mortality.Methods. From the Oslo University Hospital cohort, 277 SSc patients were included from 2003-2016 and compared with healthy controls. Serial echocardiographies were reevaluated in order to detect change in systolic function. Right heart catheterization was performed on patients suspected of pulmonary hypertension. Descriptive and regression analyses were conducted.Results. At baseline, LV systolic dysfunction by ejection fraction less than 50%, or a global longitudinal strain greater than −17.0%, was found in 12% and 24%, respectively. RV systolic dysfunction measured by tricuspid annular plane systolic excursion (TAPSE) less than 17 mm was evident in 10%. Follow-up echocardiography was performed after a median of 3.3 years (interquartile range [IQR] 1.5-5.6). At follow-up, LV systolic function remained stable, whereas RV function evaluated by TAPSE deteriorated (mean 23.1 to 21.7 mm, P = 0.005) equaling a 15% prevalence of RV systolic dysfunction. RV systolic function predicted mortality in multivariable models (hazard ratio 0.41, 95% confidence interval [CI] 0.19-0.90, P value 0.027), whereas LV systolic function lost predictive significance when adjusted for TAPSE.Conclusion. In this unselected and prospective study, systolic dysfunction of the LV and RV was a frequent complication of SSc. LV systolic function remained stable across the observation period, whereas RV function deteriorated and predicted mortality.

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