2024
DOI: 10.1111/jcmm.18387
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A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma

Minjun Du,
Xiangzhi Meng,
Boxuan Zhou
et al.

Abstract: We aimed to explore whether the genes associated with both platinum‐based therapy and polyamine metabolism could predict the prognosis of LUAD. We searched for the differential expression genes (DEGs) associated with platinum‐based therapy, then we interacted them with polyamine metabolism‐related genes to obtain hub genes. Subsequently, we analysed the main immune cell populations in LUAD using the scRNA‐seq data, and evaluated the activity of polyamine metabolism of different cell subpopulations. The DEGs be… Show more

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