2024
DOI: 10.1038/s41467-024-51134-x
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A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes

Anna Halama,
Shaza Zaghlool,
Gaurav Thareja
et al.

Abstract: In-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes Qatar Metabolomics Study of Diabetes (QMDiab). Using 6,304 quantitative molecular traits with 1,221,345 genetic variants, methylation at 470,837 DNA CpG sites, and gene expression of 57,000 transcripts, we deter… Show more

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