“…Prior to computing Haar wavelet responses, we identify a reproducible orientation of the image, which is then used to rotate the image. For that purpose, we first compute the centres of the optic disc and macula relying on the method proposed by Rust et al in [24]. Let, (x M , y M ) and (x OD , y OD ) are the coordinates of the optic disk and macula center respective, then the reproducible orientation of the image 𝜃 is computed as,…”