A robust approach to make inorganic nanovectors biotraceable

Wen, Huang; Närvänen, Ale; Jokivarsi, Kimmo; Poutiainen, Pekka; Xu, Wujun; Lehto, Vesa‐Pekka

doi:10.1016/j.ijpharm.2022.122040

Cited by 2 publications

(3 citation statements)

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“…(5) PEG-99m Tc-BP-PSi or PEG-68 Ga-BP-PSi NPs: the PEGylated NPs were prepared based on a previous report [24]. In the present study, PEG-silanes consisting of 0.5 kDa (100 µL) and 2 kDa (50 mg) were mixed with 1 mL of ethanol.…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

“…Based on our previous work, PSi NPs were prepared using an electrochemical etching method [31]. BP molecules were then conjugated on the surfaces of the PSi NPs via a hydrosilylation reaction with Si-H groups to obtain BP-PSi NPs, in which the BP molecules chelated 99m Tc or 68 Ga ions with a high affinity [24]. The shapes of the NPs were imaged with TEM measurements.…”

Section: Physiochemical Characterizations Of Psi-based Platformmentioning

confidence: 99%

“…Several studies have demonstrated the potential of DOX-loaded NPs, e.g., chitosan [17][18][19], poly(lactic-co-glycolic acid) [20,21], and mesoporous silica NPs [22,23], in the chemotherapy of TNBC. The unique properties of PSi NPs, such as their biodegradability, bioabsorbability, and high surface area for efficient drug loading, make them ideal for DOX loading [16,24,25]. Additionally, multimodal nuclear medicine imaging techniques, such as SPECT/CT (single-photon emission computed tomography/computed tomography) and PET/CT (positron emission tomography/computed tomography), have enabled the real-time monitoring of drug delivery in vivo and in vitro because of their remarkable precision and accuracy [26,27].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomimetic Inorganic Nanovectors as Tumor-Targeting Theranostic Platform against Triple-Negative Breast Cancer

Wen,

Poutiainen,

Batnasan

et al. 2023

Pharmaceutics

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Mesoporous silicon nanoparticles (PSi NPs) are promising platforms of nanomedicine because of their good compatibility, high payload capacities of anticancer drugs, and easy chemical modification. Here, PSi surfaces were functionalized with bisphosphonates (BP) for radiolabeling, loaded with doxorubicin (DOX) for chemotherapy, and the NPs were coated with cancer cell membrane (CCm) for homotypic cancer targeting. To enhance the CCm coating, the NP surfaces were covered with polyethylene glycol prior to the CCm coating. The effects of the BP amount and pH conditions on the radiolabeling efficacy were studied. The maximum BP was (2.27 wt%) on the PSi surfaces, and higher radiochemical yields were obtained for 99mTc (97% ± 2%) and 68Ga (94.6% ± 0.2%) under optimized pH conditions (pH = 5). The biomimetic NPs exhibited a good radiochemical and colloidal stability in phosphate-buffered saline and cell medium. In vitro studies demonstrated that the biomimetic NPs exhibited an enhanced cellular uptake and increased delivery of DOX to cancer cells, resulting in better chemotherapy than free DOX or pure NPs. Altogether, these findings indicate the potential of the developed platform for cancer treatment and diagnosis.

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Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Section: Physiochemical Characterizations Of Psi-based Platformmentioning

confidence: 99%