A robust ROS generation nanoplatform combating periodontitis via sonodynamic/chemodynamic combination therapy

Smart dental materials for antimicrobial applications

“…The work showed the synergistic effect of both therapies and envisioned the technology for decontamination of dental implant surfaces. A combination between SDT and chemodynamic therapy was proposed after using a nano-sonosensitizer prepared by growing titanium oxide on dendritic silica [ 316 ]. The solution was placed in a periodontal pocket in-vivo to treat periodontal disease.…”

Recent advances on nanomaterials for antibacterial treatment of oral diseases

“…The antibacterial properties of silver were discovered in ancient Greece and recent researches have showed the antibacterial effects of nano-Ag are superior to that of other nano-agents [ [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] ]. Ag has broad spectrum antibacterial activity, which is effective against Gram-positive bacteria, Gram-negative bacteria, fungi and viruses.…”

“…Xin et al. designed a novel nano-sonosensitizer was prepared for generating robust ROS through growing TiO 2 on large pore mesoporous silica nanoparticles (DLMSNs) followed by deposition of Ag (DT-Ag) and modifying with the quaternary ammonium chitosan (DT-Ag-CS+) [ 41 ]. The results of showed that DT-Ag-CS ​+ ​almost completely killed Porphyromonas gingivalis ( P. gingivalis ) in vitro , and in vivo experiments also showed the low bacterial survival rate of only 19.3%, demonstrating its potential in the treatment of periodontitis.…”

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

“…To combat periodontitis, Xin et al grew TiO 2 on dendritic large pore mesoporous silica nanoparticles (DLMSNs) to obtain a nanoparticle-based sonosensitizer (DT-Ag) and subsequently modified it with QCS to obtain DT-Ag-CS + as shown in Figure 35. 194 In the system, chitosan is designed to penetrate into the bacterial cell. Then by subjecting DT-Ag-CS + with ultrasound treatment, abundant ROS were generated due to decreasing bandgap of DT-Ag hence favoring the ROS generation reaction and thus killing the bacteria present.…”