A role for extrarenal cells in the regeneration following acute renal failure

Gupta, Sandeep K.; Verfaillie, Catherine M.; Chmielewski, David; Kim, Youngki; Rosenberg, Mark E.

doi:10.1046/j.1523-1755.2002.00569.x

Cited by 110 publications

(153 citation statements)

References 36 publications

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“…It has been suggested that, while liver disease may alter the course of renal injury, exogenous administration of regulatory factors produced by extrarenal organs may play a therapeutic role in ARF [6,10] . Thus, the aim of the present study was to examine the effects of different periods of renal ischemia on rat liver function, histology, cytokine levels and antioxidant status.…”

Section: Introductionmentioning

confidence: 99%

Effects of different periods of renal ischemia on liver as a remote organ

Kadkhodaee

Golab²,

Zahmatkesh³

et al. 2009

WJG

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AIM:To assess the hepatic changes after induction of different periods of renal ischemia. METHODS:Rats were subjected to either sham operation or ischemia (30, 45 and 60 min) followed by 60 min reperfusion. Liver and renal functional indices were measured. Hepatic glutathione (GSH) and ferric reducing antioxidant power levels and the concentration of interleukin (IL)-10 and tumor necrosis factor (TNF-α) were evaluated. Portions of liver and kidney tissues were fixed for histological evaluation. RESULTS:Forty-five minutes renal ischemia followed by 60 min reperfusion caused significant changes in liver structure and a significant reduction in renal function. These rats showed a significant decrease in liver GSH, as well as a significant increase in TNF-α and IL-10 concentrations. These results demonstrated that renal ischemia caused changes in liver histology, function, oxidative stress and inflammatory status, which led to a reduction in hepatic antioxidant capacity. With 30 min ischemia, the magnitude of these changes was less than those with 45 or 60 min ischemia. CONCLUSION:A minimum of 45 min ischemia is needed to study the effects of renal injury on the liver as a remote organ.

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Section: Introductionmentioning

confidence: 99%

Effects of different periods of renal ischemia on liver as a remote organ

Kadkhodaee

Golab²,

Zahmatkesh³

et al. 2009

WJG

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“…The use of cell therapy has been suggested as a potential modality to improve the course and outcome of kidney injury [8] . When female kidneys were transplanted into male recipients, Y chromosome-bearing cells were found in the transplanted kidney.…”

Section: Discussionmentioning

confidence: 99%

Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats

Sakr

Rashed

Zarouk

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…Unlike MSC, MAPC can be cultured indefinitely in a relatively nutrient-poor medium. MAPC exhibit many of the features and capabilities of embryonic stem cells [14][15][16][17][18][19][20][21][22][23][24].…”

Section: Multipotent Adult Progenitor Cellsmentioning

confidence: 99%

“…In patients in whom autologous bone marrow cells were injected directly into the damaged myocardium, some improvement in cardiac function was documented based on medication use, quality of life and MRI studies [17]. In a separate study, after autologous AC 133+ bone marrow cells were injected into infarction borders following coronary artery bypass grafting (CABG), improved perfusion and cardiac function may have occurred [18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Demonstration Of Bone Marrow Plasticitymentioning

confidence: 99%