2022
DOI: 10.1101/2022.06.06.495008
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A role for Flipons and miRNAs in Promoter Specification during Development

Abstract: The classical view of gene regulation is based on prokaryotic models and the operon concept with protein-based transcription factors controlling the expression of metabolic pathways essential for bacterial adaptations in response to environmental changes. A new view for establishing cell identity is emerging in eukaryotes where RNA-based pathways provide the framework for the readout of genomic information. Another perspective poses that alternative DNA structures encoded by flipons enable switching of cellula… Show more

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