2023
DOI: 10.3389/fnmol.2023.1254854
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A role for pathogenic autoantibodies in small fiber neuropathy?

Omar Daifallah,
Adham Farah,
John M. Dawes

Abstract: The immune system has a role in neuropathic pain which includes autoimmune mechanisms (e.g., autoantibodies). Clinical studies have identified a number of conditions where neuropathic pain is common and that are associated with autoantibodies targeting antigens within the nervous system. Interestingly sensory symptoms can be relieved with immunotherapies or plasma exchange, suggesting that pain in these patients is antibody-mediated. Recent preclinical studies have directly addressed this. For example, passive… Show more

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Cited by 4 publications
(3 citation statements)
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“…Blood testing confirmed idiopathic attribution ( Table ); again, autoantibody testing was not yet available. 4 Owing to symptom severity and recent nonresolving tempo, on d99, oral prednisone 1 mg/kg/d was tried empirically, with major improvement within 2 weeks and 100% remission within 2 months, maintained throughout slow prednisone taper (221-day use).…”
Section: Resultsmentioning
confidence: 99%
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“…Blood testing confirmed idiopathic attribution ( Table ); again, autoantibody testing was not yet available. 4 Owing to symptom severity and recent nonresolving tempo, on d99, oral prednisone 1 mg/kg/d was tried empirically, with major improvement within 2 weeks and 100% remission within 2 months, maintained throughout slow prednisone taper (221-day use).…”
Section: Resultsmentioning
confidence: 99%
“…Other associations are accruing with autoantibodies and aberrant innate immunity. 4 Satisfying Witebsky postulates for establishing conditions because autoimmune, independent passive transfer experiments reproduced SFN symptoms and pathology in mice injected with IgG from patients with iiSFN. 5 , 6 Population “clinical clues” include excess prevalences of comorbid autoimmune conditions (particularly Sjögren syndrome), 7 , 8 blood inflammatory markers, 2 autoantibodies, 4 , 9 and immunoglobulin deficiencies.…”
Section: Introductionmentioning
confidence: 99%
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