A Role for the Locus Coeruleus in the Modulation of Feeding

Sciolino, Natale R.; Hsiang, Madeline; Mazzone, Christopher M.; Wilson, Leslie R.; Plummer, Nicholas W.; Amin, Jaisal; Smith, Kathleen G.; McGee, Christopher; Fry, Sydney A.; Yang, Cindy X.; Powell, Jeanne M.; Bruchas, Michael R.; Kravitz, Alexxai V.; Cushman, Jesse D.; Krashes, Michael J.; Cui, Guohong; Jensen, Patricia

doi:10.1101/2019.12.18.881599

Cited by 11 publications

(11 citation statements)

References 105 publications

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“…To test for non-social reward response, mice were given a snack (chocolate pellet). As recently reported 40 , snack consumption by satiated mice (food and water was provided ad libitum to all experimental animals, see Methods) was accompanied by a drop in Ca 2+ signal that was not significant (Fig. 5B, C; baseline: -0.48 ± 0.21 Z-score; snacks: -0.81 ± 0.35 Z-score; paired t-test, p = 0.14).…”

Section: Pup Retrieval Activity In Lc Is Distinct From Non-social Motor or Reward Responsessupporting

confidence: 63%

Precise and pervasive phasic bursting in locus coeruleus during maternal behavior

Dvorkin

Shea

2021

Preprint

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The noradrenergic locus coeruleus (LC) mediates key aspects of arousal, memory, and cognition in structured tasks, but its contribution to natural behavior remains unclear. Neuronal activity in LC is organized into sustained ('tonic') firing patterns reflecting global brain states and rapidly fluctuating ('phasic') bursts signaling discrete behaviorally significant events. LC's broad participation in social behavior including maternal behavior is well-established, yet the temporal relationship of its activity to sensory events and behavioral decisions in this context is unknown. Here, we made electrical and optical recordings from LC in female mice during maternal interaction with pups. We find that pup retrieval stably elicits precisely timed and pervasive phasic activation of LC that can't be attributed to sensory stimuli, motor activity, or reward. Correlation of LC activity with retrieval events shows that phasic events are most closely related to subsequent behavior. We conclude that LC likely drives goal-directed action selection during social behavior with globally-broadcast noradrenaline release.

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Section: Pup Retrieval Activity In Lc Is Distinct From Non-social Motor or Reward Responsessupporting

confidence: 63%

Precise and pervasive phasic bursting in locus coeruleus during maternal behavior

Dvorkin

Shea

2021

Preprint

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“…Since its original publication, we have redesigned the FED twice and here present the 3 rd version of FED, which revamps our original design and adds the ability to measure operant behavior, as well as a unique "angled" pellet dispenser mechanism that is resistant to jamming. We distributed the design for FED3 online and it has been used to study how specific neural circuit manipulations alter food motivation (Mazzone et al, 2020;Sciolino et al, 2019;Vachez et al, 2021), how weight-loss alters food motivation (Matikainen-Ankney et al, 2020), and how food motivation is altered in a stress-susceptible mouse population (Rodriguez et al, 2020). FED3 is a stand-alone solution for home-cage operant training, enabling researchers to understand not just total food intake, but also motivation for and learning about food rewards.…”

Section: Discussionmentioning

confidence: 99%

An open-source device for measuring food intake and operant behavior in rodent home-cages

Matikainen‐Ankney

Earnest

Ali

et al. 2021

eLife

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Feeding is critical for survival and disruption in the mechanisms that govern food intake underlie disorders such as obesity and anorexia nervosa. It is important to understand both food intake and food motivation to reveal mechanisms underlying feeding disorders. Operant behavioral testing can be used to measure the motivational component to feeding, but most food intake monitoring systems do not measure operant behavior. Here, we present a new solution for monitoring both food intake and motivation in rodent home-cages: The Feeding Experimentation Device version 3 (FED3). FED3 measures food intake and operant behavior in rodent home-cages, enabling longitudinal studies of feeding behavior with minimal experimenter intervention. It has a programmable output for synchronizing behavior with optogenetic stimulation or neural recordings. Finally, FED3 design files are open-source and freely available, allowing researchers to modify FED3 to suit their needs.

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“…Often, the area where Mes5 neurons are located is referred to as the pre- or peri-locus coeruleus, with no effort to distinguish Mes5 neurons cytochemically [ 47 , 48 ]. It is worth noting that many of the aforementioned nuclei have well-documented roles as CNS nuclei of relevance to food intake control [ 49 , 50 , 51 , 52 , 53 ]. Thus, it is possible that prior work targeting these structures in assessing feeding behavior may have also inadvertently affected the neural processing of the Mes5.…”

Section: Discussionmentioning

confidence: 99%

The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections

et al. 2021

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The mesencephalic trigeminal nucleus (Mes5) processes oral sensory–motor information, but its role in the control of energy balance remains unexplored. Here, using fluorescent in situ hybridization, we show that the Mes5 expresses the melanocortin-4 receptor. Consistent with MC4R activation in other areas of the brain, we found that Mes5 microinjection of the MC4R agonist melanotan-II (MTII) suppresses food intake and body weight in the mouse. Furthermore, NTS POMC-projecting neurons to the Mes5 can be chemogenetically activated to drive a suppression in food intake. Taken together, these findings highlight the Mes5 as a novel target of melanocortinergic control of food intake and body weight regulation, although elucidating the endogenous role of this circuit requires future study. While we observed the sufficiency of Mes5 MC4Rs for food intake and body weight suppression, these receptors do not appear to be necessary for food intake or body weight control. Collectively, the data presented here support the functional relevance of the NTS POMC to Mes5 projection pathway as a novel circuit that can be targeted to modulate food intake and body weight.

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A Role for the Locus Coeruleus in the Modulation of Feeding

Cited by 11 publications

References 105 publications

Precise and pervasive phasic bursting in locus coeruleus during maternal behavior

Precise and pervasive phasic bursting in locus coeruleus during maternal behavior

An open-source device for measuring food intake and operant behavior in rodent home-cages

The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections

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