2010
DOI: 10.1016/j.cbpa.2010.02.005
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A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis

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Cited by 30 publications
(14 citation statements)
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“…Using traditional positional cloning and RNA-seq analysis, we determined that the split top mutant is deficient in the cathepsin Ba (ctsba) gene. Ctsba is a lysosomal endopeptidase, which has previously been suggested to be a positive regulator of apoptosis in zebrafish ovarian follicles and to play a role in modifying or degrading the extracellular matrix during fin regeneration (Eykelbosh and Van Der Kraak, 2010;Saxena et al, 2012). Here, we reveal a novel role for Ctsba in dorsoventral axial patterning and early embryonic morphogenesis.…”
Section: Introductionmentioning
confidence: 75%
“…Using traditional positional cloning and RNA-seq analysis, we determined that the split top mutant is deficient in the cathepsin Ba (ctsba) gene. Ctsba is a lysosomal endopeptidase, which has previously been suggested to be a positive regulator of apoptosis in zebrafish ovarian follicles and to play a role in modifying or degrading the extracellular matrix during fin regeneration (Eykelbosh and Van Der Kraak, 2010;Saxena et al, 2012). Here, we reveal a novel role for Ctsba in dorsoventral axial patterning and early embryonic morphogenesis.…”
Section: Introductionmentioning
confidence: 75%
“…It is important to note that during this phase the number of developing oocytes is regulated by atresia. The correct degradation of the yolk from atretic follicles and its recovery by growing oocytes ensures the reproductive performance of fish (Luckenbach et al 2008;Eykelbosh and Van Der Kraak 2010;Lubzens et al 2010;Thomé et al 2012).…”
Section: Discussionmentioning
confidence: 99%
“…In zebrafish, it has been shown that atresia of vitellogenic oocytes is associated with both granulosa cell apoptosis and the proteolytic degradation of yolk proteins within the atretic oocyte (Eykelbosh and Van Der Kraak 2010;Ucuncu and Cakici 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Cathepsin B is different from other cathepsins in that it functions as an endopeptidase at neutral pH and can be found outside of lysosomes including in the cytoplasm, at the plasma membrane, and in the extracellular space. Cathepsin B contributes to various biological processes including inflammation, cancer metastasis, apoptosis, and differentiation (37)(38)(39)(40)(41).…”
mentioning
confidence: 99%