A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer

Abstract

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common to psoriasis and cancer, including the interaction between cell proliferation and an abnormal immune microenvironment, metabolic reprogramming, and epigenetic reprogramming. In addition, there are common therapeutic agents and drug targets between psoriasis and cancer. Thus, psoriasis and cancer share a common pathological mechanisms–drug targets–therapeutic agents framework. On this basis, it is proposed that investigating psoriasis from a cancer perspective is beneficial to enriching the research strategies related to psoriasis.

Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab

“…This mechanism is particularly significant in autoimmune arthritic conditions, including rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis [ 21 ]. Targeting MAPK pathways has been explored as a therapeutic strategy for psoriasis [ 20 , 22 ]. Inhibitors of MAPK pathways, such as JNK inhibitors, ERK inhibitors, and p38 MAPK inhibitors, are being investigated for their potential to control the inflammatory and proliferative processes associated with psoriasis [ 23–26 ].…”

Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis

“…Further research has suggested that increased susceptibility to cancer in psoriasis patients is considered to be affected by factors, such as impaired immune surveillance, immunomodulatory therapy, chronic inflammation, obesity, and other commonly shared risk factors [ 3 , 5 ]. Abnormal immunoinflammatory microenvironment and cell proliferation form a vicious cycle that plays a role in psoriasis and cancer, promoting keratinocyte proliferation in psoriasis and tumor cell proliferation in cancer [ 6 – 8 ]. In the past decades, studies on the mechanism of the two diseases have mainly focused on immune and inflammatory abnormalities.…”

Excimer Laser System: The Revolutionary Way to Treat Psoriasis

“…It is linked to various comorbidities, including a higher risk of early atherosclerosis in patients, the buildup of plaque in arteries leading to cardiovascular diseases. Additionally, psoriasis has been associated with other inflammatory conditions, such as inflammatory bowel disease, which indicates that it may have a broader impact on the body beyond just the skin and joints [4].…”

“…This suggests 1 that some common factors may be shared between psoriasis and cancer, such as dysregulated cell signaling pathways and immune dysfunction. Further research is needed to fully understand the complex interplay between these factors and their contribution to the development and progression of psoriasis [4].…”