A safe bioadhesive system for topical delivery of combined antimicrobials in treatment of skin infections in veterinary medicine

Türkmen, Ece; Parmaksız, Selin; Nigiz, Şeyma; Sağıroğlu, Meral; Şenel, Sevda

doi:10.1016/j.jddst.2022.104116

Cited by 3 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitosan gels, films, and fluorinated methacrylamide chitosan hydrogel facilitate tissue repair and healing by improving the organization of collagen fibers in wounds, as shown in the example of excisional back wounds both clean and contaminated with S. aureus in rats [ 54 , 69 , 75 , 76 ].…”

Section: Application Of Biodegradable Polymers In Veterinary Medicinementioning

confidence: 99%

Biodegradable Polymers in Veterinary Medicine—A Review

Broda,

Yelle,

Serwańska-Leja

2024

Molecules

View full text Add to dashboard Cite

During the past two decades, tremendous progress has been made in the development of biodegradable polymeric materials for various industrial applications, including human and veterinary medicine. They are promising alternatives to commonly used non-degradable polymers to combat the global plastic waste crisis. Among biodegradable polymers used, or potentially applicable to, veterinary medicine are natural polysaccharides, such as chitin, chitosan, and cellulose as well as various polyesters, including poly(ε-caprolactone), polylactic acid, poly(lactic-co-glycolic acid), and polyhydroxyalkanoates produced by bacteria. They can be used as implants, drug carriers, or biomaterials in tissue engineering and wound management. Their use in veterinary practice depends on their biocompatibility, inertness to living tissue, mechanical resistance, and sorption characteristics. They must be designed specifically to fit their purpose, whether it be: (1) facilitating new tissue growth and allowing for controlled interactions with living cells or cell-growth factors, (2) having mechanical properties that address functionality when applied as implants, or (3) having controlled degradability to deliver drugs to their targeted location when applied as drug-delivery vehicles. This paper aims to present recent developments in the research on biodegradable polymers in veterinary medicine and highlight the challenges and future perspectives in this area.

show abstract

Section: Application Of Biodegradable Polymers In Veterinary Medicinementioning

confidence: 99%

Biodegradable Polymers in Veterinary Medicine—A Review

Broda,

Yelle,

Serwańska-Leja

2024

Molecules

View full text Add to dashboard Cite

show abstract

An Overview of Polymeric Nanoplatforms to Deliver Veterinary Antimicrobials

Zhou,

Guo,

Dai

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

There is an urgent need to find new solutions for the global dilemma of increasing antibiotic resistance in humans and animals. Modifying the performance of existing antibiotics using the nanocarrier drug delivery system (DDS) is a good option considering economic costs, labor costs, and time investment compared to the development of new antibiotics. Numerous studies on nanomedicine carriers that can be used for humans are available in the literature, but relatively few studies have been reported specifically for veterinary pharmaceutical products. Polymer-based nano-DDS are becoming a research hotspot in the pharmaceutical industry owing to their advantages, such as stability and modifiability. This review presents current research progress on polymer-based nanodelivery systems for veterinary antimicrobial drugs, focusing on the role of polymeric materials in enhancing drug performance. The use of polymer-based nanoformulations improves treatment compliance in livestock and companion animals, thereby reducing the workload of managers. Although promising advances have been made, many obstacles remain to be addressed before nanoformulations can be used in a clinical setting. Some crucial issues currently facing this field, including toxicity, quality control, and mass production, are discussed in this review. With the continuous optimization of nanotechnology, polymer-based DDS has shown its potential in reducing antibiotic resistance to veterinary medicines.

show abstract

Applications of Chitosan in Prevention and Treatment Strategies of Infectious Diseases

Sinani,

Sessevmez,

Şenel

2024

Pharmaceutics

View full text Add to dashboard Cite

Chitosan is the most commonly investigated functional cationic biopolymer in a wide range of medical applications due to its promising properties such as biocompatibility, biodegradability, and bioadhesivity, as well as its numerous bioactive properties. Within the last three decades, chitosan and its derivatives have been investigated as biomaterials for drug and vaccine delivery systems, besides for their bioactive properties. Due to the functional groups in its structure, it is possible to tailor the delivery systems with desired properties. There has been a great interest in the application of chitosan-based systems also for the prevention and treatment of infectious diseases, specifically due to their antimicrobial, antiviral, and immunostimulatory effects. In this review, recent applications of chitosan in the prevention and treatment of infectious diseases are reviewed, and possibilities and limitations with regards to technical and regulatory aspects are discussed. Finally, the future perspectives on utilization of chitosan as a biomaterial are discussed.

show abstract

A safe bioadhesive system for topical delivery of combined antimicrobials in treatment of skin infections in veterinary medicine

Cited by 3 publications

References 64 publications

Biodegradable Polymers in Veterinary Medicine—A Review

Biodegradable Polymers in Veterinary Medicine—A Review

An Overview of Polymeric Nanoplatforms to Deliver Veterinary Antimicrobials

Applications of Chitosan in Prevention and Treatment Strategies of Infectious Diseases

Contact Info

Product

Resources

About