A scaling law for oriented s-p excitation in ion-atom collisions

Hansen, J. P.; Hansteen, J.M.

doi:10.1088/0953-4075/25/7/005

Cited by 29 publications

(25 citation statements)

References 6 publications

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“…[10][11][12] Cocaine is highly lipophilic, so much so that treatment of cocaine overdose includes the administration of lipid emulsions to dampen its effects. 13 Cocaine is also hydrophilic; the hydrochloride salt is readily soluble in aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

“…Administered both as the hydrochloride salt and in its freebase form, both forms of cocaine are very addictive and have similar pharmacological effects. 14,15 Although it has been stated that cocaine is active only in its protonated form and that cocaine crosses the BBB only as a freebase (or in its deprotonated form), 16 this is not necessarily the case, 17 especially given that crystallographic investigations of cocaine molecules bound into a protein receptor the cocaine molecule appear to be deprotonated 12 and measurement of cocaine as it crosses the BBB in vivo is not yet possible.…”

Section: Introductionmentioning

confidence: 99%

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On the atomic structure of cocaine in solution

Johnston

Büsch

Pardo

et al. 2016

Phys. Chem. Chem. Phys.

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Cocaine is an amphiphilic drug which has the ability to cross the blood-brain barrier (BBB). Here, a combination of neutron diffraction and computation has been used to investigate the atomic scale structure of cocaine in aqueous solutions. Both the observed conformation and hydration of cocaine appear to contribute to its ability to cross hydrophobic layers afforded by the BBB, as the average conformation yields a structure which might allow cocaine to shield its hydrophilic regions from a lipophilic environment. Specifically, the carbonyl oxygens and amine group on cocaine, on average, form ∼5 bonds with the water molecules in the surrounding solvent, and the top 30% of water molecules within 4 Å of cocaine are localized in the cavity formed by an internal hydrogen bond within the cocaine molecule. This water mediated internal hydrogen bonding suggests a mechanism of interaction between cocaine and the BBB that negates the need for deprotonation prior to interaction with the lipophilic portions of this barrier. This finding also has important implications for understanding how neurologically active molecules are able to interact with both the blood stream and BBB and emphasizes the use of structural measurements in solution in order to understand important biological function.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

On the atomic structure of cocaine in solution

Johnston

Büsch

Pardo

et al. 2016

Phys. Chem. Chem. Phys.

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“…Also, the orientation phenomena in electron-ion or electron-atom collisions [5][6][7][8] have been investigated since these phenomena provide an understanding of the characteristics of plasmas. Recent experimental investigations demonstrate the possibility of the detection of radiative transitions from excited p ±1 (m = ±1) states to the ground state [8].…”

Section: Introductionmentioning

confidence: 99%

Melting Point of Superconducting Oxides as a Function of Oxygen Partial Pressure

Idemoto

Fueki

1990

Jpn. J. Appl. Phys.

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The orientation phenomena for the 1s → 2p ±1 transitions in electron-ion collisional excitations in kappa-Maxwellian plasmas are investigated by using the dynamic interaction potential. The plasma dielectric function in kappa-Maxwellian plasmas is used to obtain the scaled transition probabilities for the 1s → 2p ±1 excitations. The semiclassical straight-line trajectory approximation is applied to the motion of the projectile electron in order to visualize the variation of the dynamic orientation parameter as a function of the impact parameter, collision energy, projectile energy and spectral index κ. It is found that the probability of the m = −1 transition is suddenly increased for 1.5 < κ < 2 and is slightly decreased for κ > 2 for the small velocity ratio (v/v ). It is also found that the probability of the m = −1 transition is decreased for v/v < 2 and increased for v/v > 2. The probability of the m = −1 transition is found to be maximum near the first Bohr radius of the target ion. In addition, the probability of the m = −1 transition is also found to decrease with decreasing Debye length.

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“…7 Since then the orientation phenomena in the atomic transitions have been actively investigated because these phenomena provide detailed information on the mechanism of the collisional excitations of the target system. [8][9][10] The interaction potential in classical plasmas has been usually represented by the Yukawa-type Debye-H€ uckel model since the average energy of interaction between charged particles is smaller than the average kinetic energy of a particle. 11,12 Moreover, it is found that with an increase of the plasma density the multiparticle correlation caused by simultaneous interaction of many charged particles should be taken into account to describe the effective interaction potential in dense plasmas.…”

Section: Introductionmentioning

confidence: 99%

Orientation phenomena for the 1s → 2p±1 atomic collisional excitations in quantum plasmas: Shielding and plasmon coupling

Jung

2012

Physics of Plasmas

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The influence of the plasmon coupling on the orientation phenomena for the 1s ! 2p 61 atomic collisional transitions is investigated in quantum plasmas. The effective Hamiltonan model taking into account the quantum and plasma shielding effects is applied to describe the electronhydrogenic ion interaction in quantum plasmas. The semiclassical method is employed to describe the states of the projectile electron and target system in order to investigate the variation of the collisional orientation parameter as a function of the impact parameter, plasmon coupling parameter, collision energy, and Debye length. The variation and preference of the excitation probabilities due to the shielding and plasma coupling effects are also discussed. V C 2012 American Institute of Physics. [http://dx.

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A scaling law for oriented s-p excitation in ion-atom collisions

Cited by 29 publications

References 6 publications

On the atomic structure of cocaine in solution

On the atomic structure of cocaine in solution

Melting Point of Superconducting Oxides as a Function of Oxygen Partial Pressure

Orientation phenomena for the 1s → 2p±1 atomic collisional excitations in quantum plasmas: Shielding and plasmon coupling

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