A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds

Batista, João Vitor da Costa; Uecker, Annekathrin; Holandino, Carla; Boylan, Fábio; Maier, J; Huwyler, Jörg; Baumgartner, Stephan

doi:10.3389/fphar.2022.895838

Cited by 3 publications

(4 citation statements)

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“…Most compounds have been previously described for L. decidua ( Batista et al., 2022 ), although a few new ones were identified in this study. These were α-pinene-oxide (17), α-phellandren-8-ol (23), δ–elemene (38), cyclosative (43), ylangene (44), and butylated hydroxytoluene (57).…”

Section: Resultsmentioning

confidence: 83%

“…This oleoresin, rich in useful compounds, has been employed in various industries, from traditional medicine to perfumery and beyond ( Lagoni, 2012 ). Our recent review showed that a lot is known about the species’ phytochemical composition, but only little is known about the oleoresin’s composition and biological properties ( Batista et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

Batista,

Melo,

Holandino

et al. 2024

Front. Plant Sci.

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IntroductionLarch oleoresin has been described regarding several biological activities and medicinal applications, such as wound healing and treatment of ulcers, but little is known about its chemical composition.Material and methodsEight oleoresins from Larix decidua Mill. obtained from four companies and one adulterated control were therefore investigated to determine their content of essential oils and to verify possible differences in their composition in relation to the harvest and manufacturing processes. Essential oils (EOs) were isolated by distillation and the yield was analysed.Results and discussionThe yield of EO varied among all samples. The yield of the pure larch samples covered a range of 7.8% to 15.5%. A higher yield (19.0%) was observed for adulterated control, which contained oleoresins from different Pinaceae trees. Age of samples had no impact on yield. However, there was a significant statistical variation (p<0.05) in the yields of the mid-summer oleoresins (>10%) compared to early or late summer (<10%), emphasising the importance of the time of collection. Samples were subsequently analysed by GC-MS. EO samples confirmed the presence of various chemical classes, such as monoterpenes, sesquiterpenes, and diterpenes. α-pinene was the compound with the highest concentrations (>50%), followed by β-pinene (>6%), D-limonene (>2.5%), α-terpineol (>0.9%), β-myrcene (>0.2%), and 3-carene (>0.05%). Samples were grouped using multivariate data analysis (MVDA) with respect to the chemical variation between the oleoresins’ EOs. The resulting four clusters were named low (low yield obtained for the samples), mixed (mixed oleoresin from different Pinaceae species, adulteration control), old (old oleoresin kept in the institute), and normal (other oleoresins) samples, each presenting distinct chemical biomarkers. There were considerable differences between site and time of collection. Essential oil yield did not always meet requirements as defined by the German Homeopathic Pharmacopoeia. In addition, adulterated or aged samples could be identified as compared to pure and fresh larch oleoresins.ConclusionWe conclude that larch oleoresin used for pharmaceutical applications has to be carefully analysed and standardised to guarantee reproducible product quality.

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Section: Resultsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

Batista,

Melo,

Holandino

et al. 2024

Front. Plant Sci.

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“…The chemical composition of different parts of A. alba, L. decidua, and P. abies is well investigated [74][75][76][77][78][79][80]. The database contains the usage of needles and shoot tips of European silver fir and Norway spruce.…”

Section: Pinaceae Membersmentioning

confidence: 99%

“…Even though the Committee for Veterinary Medicinal Products from the European Medicines Agency approved the use of the resin of L. decidua for wound healing in animals due to its long history of safe topical application [87], only scarce data about its in vitro and in vivo activities is available. Substances contained in the resin of European larch contribute to an overall wound healing effect through anti-inflammatory and antimicrobial activity [74]. In vitro, the balm exhibits a pro-migratory effect on keratinocytes in a wound healing assay [73].…”

Section: Pinaceae Membersmentioning

confidence: 99%

VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine

Eichenauer,

Saukel,

Glasl

2024

Planta Med

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The global increase in the incidence of wounds is concerning and fuels the search for new treatment options. The use of traditional medicinal plants in wound healing represents an appreciated available therapeutic possibility. This work introduces the VOLKSMED database, which contains plants and other materials used in Austrian folk medicine, either as monographs or mixtures. This work focuses on the monographs of the database. Concerning wound healing, Hypericum sp., Arnica montana, Calendula officinalis, Plantago sp., and Malva sp. are the most commonly used plants. The focus of this paper is set on selected lesser-known plants (Abies alba, Anthyllis vulneraria, Brassica sp., Gentiana sp., Larix decidua, Picea abies, Sambucus sp., Sanicula europaea) and their status quo in literature concerning wound healing. A systematic search using the databases SciFinder, SCOPUS, and PubMed yielded substantial evidence for the wound healing potential of Brassica sp., Gentiana sp., the Pinaceae A. abies, L. decidua, and P. abies, as well as Sambucus nigra. In vivo and clinical studies substantiate their use in Austrian folk medicine. According to the literature, especially A. vulneraria, Sambucus racemosa, and S. europaea would be worth investigating in-depth since data concerning their wound healing effects – even though scarce – are convincing. In conclusion, the VOLKSMED database contains promising opportunities for further treatment options in the field of wound healing. Future research should consider the listed plants to support their traditional use in Austrian folk medicine and possibly promote the implementation of old knowledge in modern medicine.

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In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment

Appel,

Rose,

Zimmermann

et al. 2024

Planta Med

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An ointment containing larch turpentine, turpentine oil, and eucalyptus oil has been used for almost a century for the symptomatic treatment of mild, localized, purulent inflammations of the skin. Its clinical efficacy in the treatment of skin infections has been shown in clinical trials, but the mode of action of the active ingredients on inflammation is not known. We studied the anti-inflammatory properties of the active ingredients of the ointment and their mixture in a human monocyte cell model, in which the cells were stimulated with lipopolysaccharide and incubated with the test substances. The cytotoxic threshold of each test substance and the mixture was identified using the alamarBlue assay, and their anti-inflammatory activity was assessed by measuring the release of interleukins IL-1β, IL-6, IL-8, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α. Cell toxicity was observed at a mixture concentration of 10 µg/mL. All immunological assays were carried out at nontoxic concentrations. Larch turpentine decreased IL-1β, monocyte chemoattractant protein-1, and prostaglandin E2 release at a concentration of 3.9 µg/mL and TNF-α at concentrations > 1.95 µg/mL, whereas eucalyptus oil and turpentine oil had no relevant inhibitory effects. The mixture dose-dependently inhibited IL-1β, IL-6, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α release at concentrations > 1 µg/mL. IL-8 release was only marginally affected. The anti-inflammatory activity of the herbal ingredients and their mixture was confirmed in this model. This effect seems to be mediated mainly by larch turpentine, with turpentine oil and eucalyptus oil exerting an additive or possibly synergistic function.

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A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds

Cited by 3 publications

References 88 publications

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine

In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment

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