A "Scurvy-Like" Disease in Chicks

The Anticoagulant Effects in Rabbits and Man of the Intravenous Injection of Salts of the Rare Earths

“…12, Figure 3). We consider this phenomenon to be related to the lengthened coagulation time rather than the anticoagulant, for both internal and external hemorrhage have been reported when blood clotting time is greatly prolonged in heparin administration (18), in sweetclover disease of cattle (19), and in hemorrhagic disease of chicks (20). Accordingly this complication was not considered to be a toxic manifestation peculiar to neodymium itself.…”

Vitamin K.

“…The ketone, isolated as the semicarbazone, proved to be identical with the semicarbazone of 2,6,10trimethylpentadecanone-14 (111). One product, an acid having the composition C17Hl606 and melting a t 2O9-21O0C., was identified as 1 , 4-diacetoxy-Z-methylnaphthalene-3acetic acid (11) by comparison of the methyl ester with a synthetic specimen.…”

Vitamin K1 (Phylloquinone)

“…The discovery of vitamin K arose from the observation in the late 1920s and early 1930s that chicks reared on a reconstituted 'sterol-free' diet developed a hemorrhagic disease characterized by a severe impairment in blood coagulation (Almquist and Stokstad, 1935;Dam, 1929Dam, , 1935Dam and Schønheyder, 1934;Holst and Halbrook, 1933;McFarlane et al, 1931;Schønheyder, 1935). The lack of sterols or fat in the diet as the cause of the disease was quickly ruled out, as haemorrhages still appeared in chicks receiving a daily supplement of cholesterol and oil from cod-liver or flax seeds.…”