A seasonal pattern in the onset of polymyalgia rheumatica and giant cell arteritis? A systematic review and meta-analysis

Hysa, Elvis; Sobrero, A.; Camellino, Dario; Rumi, Federica; Carrara, Greta; Cutolo, Maurizio; Scirè, Carlo Alberto; Cimmino, Marco A.

doi:10.1016/j.semarthrit.2020.05.023

Cited by 24 publications

(17 citation statements)

References 49 publications

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“…Overlapping incidence of GCA between Northern Europe at 14.6-43.5/ 100,000 and the ancestrally similar Olmstead County, Minnesota at 19.8/ 100,000 suggest a genetic predisposition (26,27). In other populations, GCA occurs between 1.1 and 11.1/100,000 (26,(31)(32)(33), though there are no studies from Africa, South America, or the majority of continental Asia and the Middle East. It was previously thought that GCA was uncommon in African Americans (31).…”

Section: Epidemiologymentioning

confidence: 99%

“…PMR is 3-10 times more common than GCA and is the second most frequent rheumatic disease of elderly after rheumatoid arthritis (2). Forty-sixty percent of patients with GCA have symptoms of PMR while 16-21% PMR have GCA (25,26). Age >50 is a defining feature of both GCA and PMR, and both peak around age 75, with the exception that patients with LV-GCA are typically younger between 50 and 65 (2,3,24,27,28).…”

Section: Epidemiologymentioning

confidence: 99%

“…Other granulomatous vasculitides affecting the aorta also occur earlier; CIA has a mean diagnosis of age 65 while TAK peaks between 15 and 29 (14,29). All conditions are more common in women, with increasing frequency from CIA and PMR (2:1), to cranial-GCA (almost 3:1), to LV-GCA (3:1), and finally to TAK (9:1) (3,14,(26)(27)(28)(29)(30).…”

Section: Epidemiologymentioning

confidence: 99%

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The Immunopathology of Giant Cell Arteritis Across Disease Spectra

2021

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Giant cell arteritis (GCA) is a granulomatous systemic vasculitis of large- and medium-sized arteries that affects the elderly. In recent years, advances in diagnostic imaging have revealed a greater degree of large vessel involvement than previously recognized, distinguishing classical cranial- from large vessel (LV)- GCA. GCA often co-occurs with the poorly understood inflammatory arthritis/bursitis condition polymyalgia rheumatica (PMR) and has overlapping features with other non-infectious granulomatous vasculitides that affect the aorta, namely Takayasu Arteritis (TAK) and the more recently described clinically isolated aortitis (CIA). Here, we review the literature focused on the immunopathology of GCA on the background of the three settings in which comparisons are informative: LV and cranial variants of GCA; PMR and GCA; the three granulomatous vasculitides (GCA, TAK, and CIA). We discuss overlapping and unique features between these conditions across clinical presentation, epidemiology, imaging, and conventional histology. We propose a model of GCA where abnormally activated circulating cells, especially monocytes and CD4+ T cells, enter arteries after an unknown stimulus and cooperate to destroy it and review the evidence for how this mechanistically occurs in active disease and improves with treatment.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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The Immunopathology of Giant Cell Arteritis Across Disease Spectra

2021

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“…In up to 20% of cases, PMR can be associated with giant cell arteritis (GCA), a chronic granulomatous vasculitis affecting the aorta and its branches. GCA patients, in turn, can have polymyalgic manifestations in up to 60% of cases [13]. GCA is the most common primary vasculitis in patients aged over 50 years [7,11].…”

Section: Introductionmentioning

confidence: 99%

Antimitochondrial Antibodies and Primary Biliary Cholangitis in Patients with Polymyalgia Rheumatica/Giant Cell Arteritis

Manzo

Maślińska

Castagna³

et al. 2021

Medicina

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Background and Objectives: Laboratory liver abnormalities can be observed in patients affected with polymyalgia rheumatica (PMR) and/or giant cell arteritis (GCA), especially with a cholestatic pattern. The first objective of our review article is to discuss the potential link between antimitochondrial antibodies (AMA) and/or primary biliary cholangitis (PBC) and PMR/GCA, according to the evidences of literature. The second objective is to discuss the association of PMR/GCA with the other rheumatic diseases having PBC as a common manifestation. Materials and Methods: A literature search was performed on PubMed and Medline (OVID interface) using these terms: polymyalgia rheumatica, giant cell arteritis, antimitochondrial antibodies, primary biliary cholangitis, primary Sjogren’s syndrome, systemic sclerosis, and systemic lupus erythematosus. The search was restricted to all studies and case reports published in any language. Reviews, conference abstracts, comments, and non-original articles were excluded; however, each review’s reference list was scanned for additional publications meeting this study’s aim. When papers reported data partially presented in previous articles, we referred to the most recent published data. Results and Conclusions: Our literature search highlighted that cases reporting an association between AMA, PBC and PMR/GCA were very uncommon; AMA antigenic specificity had never been detected and biopsy-proven PBC was reported only in one patient with PMR/GCA. Finally, the association of PMR/GCA with autoimmune rheumatic diseases in which PBC is relatively common was anecdotal.

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“…In this letter, our aim is to add a brief focus about the hepatic manifestations related to polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) according to the evidences of literature. Polymyalgia rheumatica is estimated to be one of the most common inflammatory rheumatic diseases affecting older adults [2]. At least 10-16% of PMR patients have also manifestations of GCA, whereas 40-60% of GCA patients have also manifestations of PMR.…”

mentioning

confidence: 99%

Liver involvement in polymyalgia rheumatica and giant cell arteritis

Hysa¹,

Castagna²,

Manzo

2020

Reumatologia

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This is a Letter to the Editor and no abstract is required. The Editorial System did not allow a proper insertion. This is a Letter to the Editor and no abstract is required. The Editorial System did not allow a proper insertion. This is a Letter to the Editor and no abstract is required. The Editorial System did not allow a proper insertion. This is a Letter to the Editor and no abstract is required. The Editorial System did not allow a proper insertion. This is a Letter to the Editor and no abstract is required.

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A seasonal pattern in the onset of polymyalgia rheumatica and giant cell arteritis? A systematic review and meta-analysis

Cited by 24 publications

References 49 publications

The Immunopathology of Giant Cell Arteritis Across Disease Spectra

The Immunopathology of Giant Cell Arteritis Across Disease Spectra

Antimitochondrial Antibodies and Primary Biliary Cholangitis in Patients with Polymyalgia Rheumatica/Giant Cell Arteritis

Liver involvement in polymyalgia rheumatica and giant cell arteritis

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