A secondary ion microprobe ion trap mass spectrometer

Todd, Peter J.; Schaaff, T. Gregory

doi:10.1016/s1044-0305(02)00434-8

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…La différence de masse entre deux peptides « fils » consécutifs sera la masse d'un acide aminé. On obtient là aussi une courte séquence d'acides aminés [65,103,127]. La trappe ionique offre une sensibilité très élevée, ainsi que la possibilité de réaliser avec un seul appareil des études structurales.…”

Section: Figureunclassified

Protéomique et hépatites auto-immunes : techniques et résultats

Ballot

Naour

Huguet

et al. 2008

Immuno-analyse & Biologie Spécialisée

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Section: Figureunclassified

Protéomique et hépatites auto-immunes : techniques et résultats

Ballot

Naour

Huguet

et al. 2008

Immuno-analyse & Biologie Spécialisée

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“…Zweir y col [5] han encontrado que las estructuras tipo "Gauge" del NH2 sobre el pirrol son las más estables. Es importante mencionar que las reacciones por transferencia protónica juegan un papel importante en una amplia variedad de procesos, biológicos, industriales y medio ambientales [6] y son cuantificados por magnitudes termodinámicas como la acidez y la basicidad/afinidad protónica.…”

Section: Introductionunclassified

Reactividad química por intercambio protónico de la serotonina

2019

Rev. ECIPeru

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ResumenSe estudió los procesos de protonación (basicidad, GB) y desprotonación (acidez, GA) en fase gaseosa de la serotonina mediante cálculos computacionales utilizando el programa Gaussian D01. El nivel de cálculo usado fue B3LYP/6-311++G(d,p) y los valores determinados fueron: GA =1421 kJmol -1 , para la serotonina desprotonada en el grupo -NH-; GB = 918,6kJmol -1 , para la forma protonada en el grupo etil-amina NH2-CH2CH2-.Descriptores: Acidez/basicidad, serotonina, B3LYP, neurotransmisor. AbstractThe serotonin protonation (basicity, GB) and deprotonation (acidity, GA) processes in the gas phase were study by computational calculations using Gaussian D01 software. The calculation level used was B3LYP/6-311++G(d,p) and the determined values were: GA = 1421 kJmol -1 , for the deprotonated serotonin in the -NHgroup; GB = 918,6 kJmol -1 , for the protonated in the ethyl-amine group NH2-CH2CH2-.

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“…This is due, in part, to the inherent lack of tandem MS (MS/MS) capabilities of TOF-SIMS instrumentation and low mass resolving power and mass accuracy. Tandem MS of secondary ions has been shown in a triple quadrupole, − an ion-trap and by TOF-SIMS, however, without the added benefit of high mass resolving power or mass measurement accuracy.…”

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C₆₀ Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

et al. 2011

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Secondary ion mass spectrometry (SIMS) has seen increased application for high spatial resolution chemical imaging of complex biological surfaces. The advent and commercial availability of cluster and polyatomic primary ion sources (e.g., Au and Bi cluster and buckminsterfullerene (C(60))) provide improved secondary ion yield and decreased fragmentation of surface species, thus improving accessibility of intact molecular ions for SIMS analysis. However, full exploitation of the advantages of these new primary ion sources has been limited, due to the use of low mass resolution mass spectrometers without tandem MS to enable enhanced structural identification capabilities. Similarly, high mass resolution and high mass measurement accuracy would greatly improve the chemical specificity of SIMS. Here we combine, for the first time, the advantages of a C(60) primary ion source with the ultrahigh mass resolving power and high mass measurement accuracy of Fourier transform ion cyclotron resonance mass spectrometry. Mass resolving power in excess of 100 000 (m/Δm(50%)) is demonstrated, with a root-mean-square mass measurement accuracy below 1 part-per-million. Imaging of mouse brain tissue at 40 μm pixel size is shown. Tandem mass spectrometry of ions from biological tissue is demonstrated and molecular formulas were assigned for fragment ion identification.

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A secondary ion microprobe ion trap mass spectrometer

Cited by 7 publications

References 17 publications

Protéomique et hépatites auto-immunes : techniques et résultats

Protéomique et hépatites auto-immunes : techniques et résultats

Reactividad química por intercambio protónico de la serotonina

C₆₀ Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

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A secondary ion microprobe ion trap mass spectrometer

Cited by 7 publications

References 17 publications

Protéomique et hépatites auto-immunes : techniques et résultats

Protéomique et hépatites auto-immunes : techniques et résultats

Reactividad química por intercambio protónico de la serotonina

C60 Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

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Product

Resources

About

C₆₀ Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry