A Sensitive and Selective Electrochemical Method for the Simultaneous Determination of Dopamine and Paracetamol based on a Multiwalled Carbon Nanotubes/Poly(<scp>l</scp>-lysine)-modified Glassy Carbon Electrode

This paper describes the development of a novel, simple, and inexpensive electrochemical device containing an integrated and disposable three‐electrode system for detection. The base of this platform consists on a PDMS structure containing microchannels which were prototyped using 3D‐printed molds. Pencil graphite leads were inserted into these microchannels and utilized as working, counter and reference electrodes in a novel design. Morphological analysis and electrochemical experiments with benchmark redox probes were carried out in order to evaluate the performance and characterize the miniaturized device proposed. Even using inexpensive materials and a simple fabrication protocol, the electrochemical platform developed provided good repeatability and reproducibility over a low cost (ca. $2 per device), acceptable lifetime (ca. 250 voltammetric runs) and extremely reduced consumption of samples and reagents (order of µL). As proof of concept, the analytical feasibility of the platform was investigated through the simultaneous determination of dopamine (DOPA) and acetaminophen (AC). The two analytes showed linear dependence on the concentration range from 1 to 15 µM and the LODs achieved were 0.21 µM for DOPA and 0.29 µM for AC. Moreover, the platform was successfully applied on the determination of DOPA and AC in spiked blood serum and urine samples. The results obtained with the device described here were better than some reports in literature that use more costly electrodic materials and complex modification steps for the detection of the same analytes.

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Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

Moraes

Silva

Petroni

et al. 2019

Electrophoresis

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Graphene micro-aerogel based voltammetric sensing of p-acetamidophenol

Ruiyi

Liu

et al. 2017

Microchim Acta

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Improving the performance and versatility of microfluidic thread electroanalytical devices by automated injection with electronic pipettes: a new and powerful 3D-printed analytical platform

de Moraes,

Carvalho,

Ferreira

et al. 2023

Microchim Acta

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A Sensitive and Selective Electrochemical Method for the Simultaneous Determination of Dopamine and Paracetamol based on a Multiwalled Carbon Nanotubes/Poly(l-lysine)-modified Glassy Carbon Electrode

Cited by 3 publications

References 20 publications

Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

Graphene micro-aerogel based voltammetric sensing of p-acetamidophenol

Improving the performance and versatility of microfluidic thread electroanalytical devices by automated injection with electronic pipettes: a new and powerful 3D-printed analytical platform

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