A Sensitive H₂O₂ Electrochemical Sensor Based on Pd Nanoparticles Decorated Ti₂NT_x MXene

Abstract

Hydrogen peroxide (H2O2), a prominent reactive oxygen species in organisms, plays a vital role in regulating fundamental biological activities and actively participates in cellular metabolism and stress response. Gaining insights into the quantifying H2O2 within living organisms has significant implications for human health research. The 2D transition metal nitride (Ti2NTx MXene) exhibits a thin crystal structure and enhanced electrical conductivity. A simple electrochemical sensing method for H2O2 is presented by employing palladium modification on Ti2NTx MXene. Characterization analysis confirmed the successful etching of the Ti2AlN MAX phase into accordion‐like morphology of Ti2NTx MXene by Li+ intercalation, and Pd NPs were uniformly dispersed onto the Ti2NTx MXene nanosheets. Electrochemical analysis revealed that optimal electrochemical detection performance for H2O2 was achieved when Ti2NTx MXene had an optimum Pd modification amount (2 wt%) at −0.4 V, exhibiting excellent stability at low concentrations. The detection limit was determined to be 0.72 µM, with a calculated sensitivity of 0.825 µA µM−1 cm−2. This study establishes the optimal amount of Pd modification and identifies Pd‐Ti2NTx MXene as a promising candidate for electrochemical sensing applications targeting H2O2.