“…This phenomenon allows the occurrence of FRET between CDots and MnO 2 . 11,[73][74][75][76][77][78][79] The transition metal oxide MoS 2 has a sandwich structure that is bonded by weak van der Waals forces and can be regarded as S-Mo-S. MoS 2 possesses a large intrinsic band gap that depends largely on the number of layers. In addition, most transition metal ions have inherent fluorescence quenching characteristics.…”
Förster resonance energy transfer (FRET) paired carbon dot composite nanoprobes are studied as multi-functional platforms for sensing and imaging applications.
“…This phenomenon allows the occurrence of FRET between CDots and MnO 2 . 11,[73][74][75][76][77][78][79] The transition metal oxide MoS 2 has a sandwich structure that is bonded by weak van der Waals forces and can be regarded as S-Mo-S. MoS 2 possesses a large intrinsic band gap that depends largely on the number of layers. In addition, most transition metal ions have inherent fluorescence quenching characteristics.…”
Förster resonance energy transfer (FRET) paired carbon dot composite nanoprobes are studied as multi-functional platforms for sensing and imaging applications.
“…The degree of fluorescence recovery was directly proportional to the GSH concentration. Apart from GSH detection, the MnO 2 -based FRET sensors have also been applied in the detections of other substances, for instance, AA [139,142], enzyme activity [138,139,141,[143][144][145][146], drugs [147], H 2 O 2 [58,133], pesticides [140], and glucose [58,137]. Similar to GSH, AA and H 2 O 2 also present strong reduction capability that could reduce the MnO 2 nanosheets into Mn 2+ .…”
Section: Mno 2 Nanosheets As the Acceptor In Fret Sensorsmentioning
confidence: 99%
“…However, for the detection of enzyme activity, the enzyme could catalyze the hydrolysis of substrate into the product that can reduce MnO 2 nanosheets into Mn 2+ [138] ( Figure 8D). Unlike the studies mentioned above, Garg et al [147] reported a novel FRET sensor for the detection of anticancer drugs, 6-thioguanine (6-TG) and 6-mercaptopurine (6-MP) based on the fluorescence recovery of carbon dots due to the formation of Mn-S bond.…”
Section: Mno 2 Nanosheets As the Acceptor In Fret Sensorsmentioning
AbstractFörster resonance energy transfer (FRET)–based sensing has been steadily gaining popularity in the areas of biochemical analysis, environmental monitoring, and disease diagnosis in the past 20 years. Two-dimensional (2D) nanomaterials are extensively used as donors and acceptors in the FRET sensing because of their attractive optical and chemical properties. In this review, we first present the FRET theory and calculations to give readers a better understanding of the FRET phenomenon. Then, we discuss the recent research advances in using 2D nanomaterials as donors and acceptor in FRET sensing. Finally, we summarize the existing challenges and future directions of 2D nanomaterials in the FRET sensing applications.
“…The nanoprobe could operate from 4 to 800 µM with an LOD of 1.33 µM, and could be further applied for 6-TG detection in human serum and urine samples. To further improve the sensitivity of the nanoprobe, Garg et al [ 258 ] developed a FRET-based system using CQDs as the electron donor and MnO 2 nanosheets or nanoflowers as the electron acceptor (Fig. 21 ).…”
Over the past decade, carbon dots have ignited a burst of interest in many different fields, including nanomedicine, solar energy, optoelectronics, energy storage, and sensing applications, owing to their excellent photoluminescence properties and the easiness to modify their optical properties through doping and functionalization. In this review, the synthesis, structural and optical properties, as well as photoluminescence mechanisms of carbon dots are first reviewed and summarized. Then, we describe a series of designs for carbon dot-based sensors and the different sensing mechanisms associated with them. Thereafter, we elaborate on recent research advances on carbon dot-based sensors for the selective and sensitive detection of a wide range of analytes, including heavy metals, cations, anions, biomolecules, biomarkers, nitroaromatic explosives, pollutants, vitamins, and drugs. Lastly, we provide a concluding perspective on the overall status, challenges, and future directions for the use of carbon dots in real-life sensing.
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