2024
DOI: 10.1007/s00204-024-03689-3
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A-series agent A-234: initial in vitro and in vivo characterization

Martina Hrabinova,
Jaroslav Pejchal,
Vendula Hepnarova
et al.

Abstract: A-series agent A-234 belongs to a new generation of nerve agents. The poisoning of a former Russian spy Sergei Skripal and his daughter in Salisbury, England, in March 2018 led to the inclusion of A-234 and other A-series agents into the Chemical Weapons Convention. Even though five years have already passed, there is still very little information on its chemical properties, biological activities, and treatment options with established antidotes. In this article, we first assessed A-234 stability in neutral pH… Show more

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Cited by 10 publications
(1 citation statement)
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“…Moreover, theoretical electrophilic of phosphorus atom was calculated, demonstrating a greater reactivity of V-series than a-series OP (Vieira et al 2021). It is also observed in experimental data in literature (Hrabinova et al 2024) that VX has a greater inhibitory potential than A-234, confirming the toxicological correlation between the neurotoxic agents in Schedule 1 of the CWC and their surrogates, demonstrating the potency and usefulness of these kind of nerve agent surrogate scaffold for toxicological assessments. Results on reactivation revealed the best performance of pralidoxime (7),…”
Section: Discussionsupporting
confidence: 62%
“…Moreover, theoretical electrophilic of phosphorus atom was calculated, demonstrating a greater reactivity of V-series than a-series OP (Vieira et al 2021). It is also observed in experimental data in literature (Hrabinova et al 2024) that VX has a greater inhibitory potential than A-234, confirming the toxicological correlation between the neurotoxic agents in Schedule 1 of the CWC and their surrogates, demonstrating the potency and usefulness of these kind of nerve agent surrogate scaffold for toxicological assessments. Results on reactivation revealed the best performance of pralidoxime (7),…”
Section: Discussionsupporting
confidence: 62%