A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria

Liu, Zhengwei; Wang, Faming; Ren, Jinsong; Qu, Xiaogang

doi:10.1016/j.biomaterials.2019.04.007

Cited by 250 publications

(187 citation statements)

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“…Extracellular DNA (eDNA) is one of the important components in the process of biofilm formation, making the biofilm hard to eliminate. Therefore, taking advantage of Ce-based nanozymes with deoxyribonuclease (DNase) mimetic activity could lead to high cleavage ability toward eDNA and disrupt established biofilms (Chen et al, 2016;Liu et al, 2019).…”

Section: Antibacterial Mechanism Of Cerium-based Materialsmentioning

confidence: 99%

“…Bacterial biofilm is one of the primary causes of antibiotic resistance and immune response resistance, which led to persistent infections and increase in the difficulties for clinical treatment (Wu et al, 2015;Liu et al, 2019). Cerium-or cerium oxide-decorated materials could effectively inhibit the formation of biofilm, disturb the established biofilm, and eliminate the biofilm (Chen et al, 2016;Liu et al, 2019;Qiu et al, 2019). Herein, CeO 2 -decorated porphyrin-based MOFs were designed to inhibit biofilm formation (Qiu et al, 2019).…”

Section: Cerium-and Cerium Oxide-decorated Materialsmentioning

confidence: 99%

“…Besides, hematoxylin and eosin (H&E) staining sections of the group treated with MOF@CeO 2 NPs and light irradiation showed a small number of inflammatory cells, while a large number of aggregated inflammatory cells were observed in the control group. In another study, MOF −2.5Au−Ce , a series of MOF/Ce-based nanozymes with dual enzyme-mimetic activities including deoxyribonuclease (DNase) and peroxidase mimetic activities, was designed and, in the presence of H 2 O 2 , had ability to penetrate the biofilms, intensively inhibit bacterial biofilm formation in vitro, and treat subcutaneous abscess in vivo (Liu et al, 2019; Figure 7). The cerium(IV) complexes could hydrolyze eDNA and disrupt established biofilms; meanwhile, in the presence of H 2 O 2 , the MOF could kill bacteria exposed in dispersed biofilms.…”

Section: Cerium-and Cerium Oxide-decorated Materialsmentioning

confidence: 99%

“…(F) Photographs of subcutaneous abscess in mice from the six groups at different times during the therapeutic process. Reprinted with permission from Liu et al (2019), copyright 2019 Elsevier. were observed with the maximum ZOI against E. coli and S. aureus and showed a lower MIC value than other groups.…”

Section: Ceo 2 Blend With Other Nanomaterialsmentioning

confidence: 99%

“…However, it was found that CeO 2 NPs at low concentrations (1 mg/L) could not destroy the bacterial biofilms (Hou et al, 2015). Therefore, various cerium-and cerium oxide-based nanomaterials including doping metal ions (Atif et al, 2019), antibacterial element Au/Ag decorations (Babu et al, 2014;Wang et al, 2014), nanocontainers (Gagnon et al, 2015), dopants (Bomila et al, 2018), and a component of blend (Pandey et al, 2018a) were developed to optimize antimicrobial performance as well as physical and biological properties (Anastasiou et al, 2019;Bharathi and Stalin, 2019;Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has helped to cure numerous infectious diseases and made huge contributions in the biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to serious drug resistance for many human bacterial pathogens. In particular, bacterial drug resistance decreases therapeutic effects and leads to high mortality. Inspiringly, the introduction of nanomaterials in the biomedical field makes it possible to overcome the difficulty in bacterial drug resistance attributed to their unique antibacterial mechanism. Recently, a variety of metal-and metal oxide-based nanomaterials have been fully integrated in antibacterial applications and achieved excellent performances. Among them, cerium-and cerium oxide-based nanomaterials have received much attention worldwide. Remarkably, cerium oxide nanoparticles with lower toxicity act as effective antibacterial agents owing to their unique functional mechanism against pathogens through the reversible conversion of oxidation state between Ce(III) and Ce(IV). This article provides an overview of the state-of-the-art design and antibacterial applications of cerium-and cerium oxidebased materials. The first part discusses the underlying antibacterial mechanisms for cerium-and cerium oxide-based materials currently applied in biomedicine. The second part focuses on various antibacterial-related materials and their applications. In addition, the existing problems and future perspectives of the cerium-and cerium oxide-based materials make up the third part of this review. This paper could provide the possible mechanisms for antibacterial activities, various designs of cerium-and cerium oxide-based materials, and related antibacterial properties.

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Section: Antibacterial Mechanism Of Cerium-based Materialsmentioning

confidence: 99%

Section: Cerium-and Cerium Oxide-decorated Materialsmentioning

confidence: 99%

Section: Cerium-and Cerium Oxide-decorated Materialsmentioning

confidence: 99%

Section: Ceo 2 Blend With Other Nanomaterialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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Metal–Organic Frameworks as Enzyme Mimics

Liebing¹,

Kulak²

2021

Encyclopedia of Inorganic and Bioinorganic Chemistry

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In this article we are presenting the design of metal–organic frameworks (MOFs) for applications as enzyme mimics (artificial enzymes). MOFs have been the topic of current and intense research for various applications ranging from gas storage, catalysis, to sensing. Their biocatalytic activity, however, has been discovered and investigated only recently—literature exists only for the past decade. High stability also at harsh conditions, low cost, and activity that can be tailored are advantages that compete oftentimes lower activity in comparison to the natural enzymes. Among the nanomaterials with enzymatic activity (nanozymes), MOFs are of special potential, since it is possible to mimic not only the active site of an enzyme but also its microenvironment. We firstly introduce MOFs along with synthetic strategies and secondly give an overview of their nanozymatic activity for oxidation and hydrolytic reactions. This activity has found many applications in biosensing and biomedicine, which are presented in the last chapter of this article. Medicinal applications cover cancer and antimicrobial therapy.

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Antifungal‐Inbuilt Metal–Organic‐Frameworks Eradicate Candida albicans Biofilms

Liu

et al. 2020

Adv Funct Materials

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Fungal biofilms cause a major clinical problem with a shrinking armamentarium for treatment. Here, the design and synthesis of voriconazole-inbuilt zinc 2-methylimidazolates frameworks (V-ZIF) is reported. Voriconazole is built in through coordination-binding between zinc and voriconazole. These metal-organic-frameworks with inbuilt voriconazole, reduce inadvertent voriconazole-leakage, yield a zero-order release kinetics of voriconazole, aid antifungal penetration in Candida albicans biofilms, and prevent Candida aggregation yielding better dispersal. Once accumulated in an acidic C. albicans biofilm, voriconazole dissociates from the metal-organic framework to cause membrane-damage and killing of inhabiting fungi. Moreover, in a murine model, the V-ZIFs eradicate open-wound infections caused by C. albicans better than voriconazole in solution, with negligible side effects to the healthy tissues of major organs. Thus, V-ZIFs may provide a welcome addition to the antifungal armamentarium currently available for the treatment of fungal biofilms.

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A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria

Cited by 250 publications

References 69 publications

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Metal–Organic Frameworks as Enzyme Mimics

Antifungal‐Inbuilt Metal–Organic‐Frameworks Eradicate Candida albicans Biofilms

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