A seroepidemiological study of human cysticercosis in West Cameroon

Nguekam, J. P.; Zoli, A; Zogo, Pierre Ongolo; Kamga, A. C. T.; Speybroeck, Niko; Dorny, Pierre; Brandt, Jef; Losson, Bertrand; Geerts, S.

doi:10.1046/j.1365-3156.2003.01000.x

Cited by 60 publications

(54 citation statements)

References 19 publications

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“…Contradictory results have been reported about the impact of sex on infection with cysticercosis. The other risk factors for cysticercosis, however, are well known and were reported previously (Garcia et al 2003;Nguekam et al 2003c). This study has focused on NCC as a cause of epilepsy.…”

Section: Discussionmentioning

confidence: 94%

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Prado-Jean

Kanobana

Druet‐Cabanac

et al. 2007

Tropical Med Int Health

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Summaryobjective To evaluate the benefits of the detection of both circulating antibodies (Ab) and antigens (Ag) for the diagnosis of cysticercosis in people with epilepsy. Neurocysticercosis is a cause of neurological diseases world-wide, especially epilepsy. The clinical symptoms of neurocysticercosis are non-specific and diagnosis is often difficult.methods Serum samples were collected from subjects in a matched case-control study for epilepsy in the Kiremba area, Burundi, between March and April 2001 (epileptic cases ¼ 303; controls without epilepsy ¼ 606). The enzyme-linked immunosorbent assay (ELISA) was used for the detection of antibodies (Ab-ELISA) and circulating Ag (Ag-ELISA).results The Ab-ELISA revealed 58.7% positivity in epilepsy cases and 31.4% in healthy controls; and Ag-ELISA revealed 38.3% positivity in epilepsy cases and 20.0% in controls. The matched odds ratios were 3.6 (95%CI: 2.5-4.9) for Ab-ELISA, and 2.9 (95%CI: 2.1-4.3) for Ag-ELISA.conclusion Both Ag-and Ab-ELISA detected a significantly higher number of seropositives among people with epilepsy than among controls. The risk of epilepsy was high in cases with a positive Ag-ELISA, although less important than in cases with positivity for Ab-ELISA. Dead or degenerating cysticerci appear to be more frequently associated with epilepsy than living cysts. The high number of people with circulating Ag of Taenia solium suggests that the study area is a focus of active transmission of the parasite.

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Section: Discussionmentioning

confidence: 94%

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Prado-Jean

Kanobana

Druet‐Cabanac

et al. 2007

Tropical Med Int Health

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“…The latter authors did show that about 40 % of seropositive people became seronegative when resampled after one to 3 years. This phenomenon, which was ascribed to the exposure to eggs of the parasite, which did not develop into a viable infection, might also be present in the study area, which is hyperendemic for T. solium Vondou et al, 2002;Nguekam et al, 2003b).…”

Section: Discussionmentioning

confidence: 94%

“…Serum samples were examined in duplicate using a monoclonal antibody based Elisa for the detection of circulating T. solium antigen (Brandt et al, 1992) slightly modified according to Nguekam et al (2003b). Each Elisa run included 8 negative reference sera and one reference positive serum from the region of Dschang in Cameroon (Nguekam et al, 2003b).…”

Section: Antigen Detection Elisa (Ag-elisa)mentioning

confidence: 99%

“…Each Elisa run included 8 negative reference sera and one reference positive serum from the region of Dschang in Cameroon (Nguekam et al, 2003b). The cut-off value was determined by comparing the optical density (OD) of each sample with the mean of a series of 8 negative reference samples using a modified Student test (Sokal & Rohlf, 1981) at a probability level of P=0.001.…”

Section: Antigen Detection Elisa (Ag-elisa)mentioning

confidence: 99%

“…Given the fact that T. solium is endemic in the western highland region of the country (Nguekam et al, 2003b), we studied the frequency of cysticercosis in epileptic patients attending health centres of the region using two serological tests (Elisa for antigen and for antibody detection).…”

Section: Introductionmentioning

confidence: 99%

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Neurocysticercosis and epilepsy in Cameroon

Zoli

Nguekam

Shey-Njila

et al. 2003

Transactions of the Royal Society of Tropical Medicine and Hygi

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Abstract:The frequency of Taenia solium cysticercosis was studied in a series of 504 epileptic patients from 3 rural localities in the West and North-west provinces of Cameroon using ELISA both for circulating antigen (Ag-Elisa) and antibody detection (Ab-Elisa). T. solium antigens were detected in the sera of 1.2% of the epileptics whereas specific antibodies against the parasite were present in 44.6% of patients. Significantly more seropositives in Ab-Elisa were recorded in Batibo than in Bandjoun and Batibo whereas a borderline significant difference was recorded with increasing age. Furthermore, 50% of patients with late-onset epilepsy showed antibodies against cysticercosis. T. solium cysticercosis appears to be an important cause of epilepsy in Cameroon.

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The Core Skills Trainer: A Set of Haptic Games for Practicing Key Clinical Skills

Baillie

Forrest

Kinnison

2010

Haptics: Generating and Perceiving Tangible Sensations

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Infection by Taenia solium poses a major burden across endemic countries. The World Health Organization (WHO) 2021-2030 Neglected Tropical Diseases roadmap has proposed that 30% of endemic countries achieve intensified T. solium control in hyperendemic areas by 2030. Understanding geographical variation in age-prevalence profiles and force-of-infection (FoI) estimates will inform intervention designs across settings. Human taeniasis (HTT) and human cysticercosis (HCC) age-prevalence data from 16 studies in Latin America, Africa, and Asia were extracted through a systematic review. Catalytic models, incorporating diagnostic performance uncertainty, were fitted to the data using Bayesian methods, to estimate rates of antibody (Ab)-seroconversion, infection acquisition and Ab-seroreversion or infection loss. HCC FoI and Ab-seroreversion rates were also estimated across 23 departments in Colombia from 28,100 individuals. Across settings, there was extensive variation in all-ages seroprevalence. Evidence for Ab-seroreversion or infection loss was found in most settings for both HTT and HCC and for HCC Ab-seroreversion in Colombia. The average duration until humans became Ab-seropositive/infected decreased as all-age (sero) prevalence increased. There was no clear relationship between the average duration humans remain Ab-seropositive and all-age seroprevalence. Marked geographical heterogeneity in T. solium transmission rates indicate the need for setting-specific intervention strategies to achieve the WHO goals. Editor's evaluationDixon and colleagues have collated published "age-prevalence" data from 16 studies (4 from South America, 8 from Africa, and 4 from Asia) to estimate the force of infection of taeniasis/human cysticercosis across diverse endemic settings. This study addresses a major knowledge gap, as little is currently known regarding the extent of current/recent Taenia solium transmission worldwide. The

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A seroepidemiological study of human cysticercosis in West Cameroon

Cited by 60 publications

References 19 publications

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Neurocysticercosis and epilepsy in Cameroon

The Core Skills Trainer: A Set of Haptic Games for Practicing Key Clinical Skills

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