A severe pediatric infection with a novel enterovirus A71 strain, Thuringia, Germany

Karrasch, Matthias; Fischer, Ernst; Scholten, Martin; Sauerbrei, Andreas; Henke, Andreas; Renz, Diane M.; Mentzel, Hans‐Joachim; Böer, Klas; Böttcher, Sindy; Diedrich, Sabine; Krumbholz, Andi; Zell, Roland

doi:10.1016/j.jcv.2016.09.007

Cited by 37 publications

(31 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, whereas EV-A71 subgenogroup C2 viruses had been predominant in France since 2006 [5,9], in 2016, the EV-A71 subgenogroup C1 viruses were predominant. These EV-A71 C1 viruses had not previously been detected in France (data not shown) and were closely related to a new cluster of EV-A71 C1 viruses detected in 2015 in Germany [10,11]. Most of the cases were diagnosed in late July, concurrently with the usual peak of EV circulation in the country, but cases were still identified in September and October.…”

Section: Discussionsupporting

confidence: 62%

Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016

et al. 2016

View full text Add to dashboard Cite

We report 59 cases of severe paediatric conditions linked with enterovirus (EV)-A71 and EV-D68 in France between May and October 2016. Fifty-two children had severe neurological symptoms. EV sequence-based typing for 42 cases revealed EV-A71 in 21 (18 subgenotype C1, detected for the first time in France) and EV-D68 in eight. Clinicians should be encouraged to obtain stool and respiratory specimens from patients presenting with severe neurological disorders for EV detection and characterisation.

show abstract

Section: Discussionsupporting

confidence: 62%

Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016

et al. 2016

View full text Add to dashboard Cite

show abstract

“…For the first time this subgenogroup was detected in Europe in 2004 . Genotype C1, detected in Poland in 2016, was closely related to a new cluster previously detected in Germany (2015) and in France (2016) . Also the analysis of 3D region revealed that the Polish isolate shares a common ancestor with the recombinant variant from Germany.…”

Section: Discussionmentioning

confidence: 60%

“…Although EV‐A71 asymptomatic circulation and sporadic, often mild, cases have been reported in European countries, epidemics with severe neurological complication have been predominantly found in the Asia‐Pacific region. Unfortunately, outbreaks and sporadic cases with severe manifestation have been noted in Europe more and more often …”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, outbreaks and sporadic cases with severe manifestation have been noted in Europe more and more often. [8][9][10][11] In Poland, the first sporadic case of AFP associated with EV-A71 infection was noted in 2013. During summer 2016, outbreak of EV-A71 infection with severe neurological cases (aseptic meningitis, cerebellitis, encephalitis, myelitis, AFP) occurred in Gdansk.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic characterization of enterovirus A71 isolates from severe neurological cases in Poland

Wieczorek

Purzyńska²,

Krzysztoszek

et al. 2017

Journal of Medical Virology

View full text Add to dashboard Cite

The aim of this study was to report a minor outbreak of enterovirus A71 (EV-A71) infection in Poland and characterize isolates from cases of severe neurological infection detected in 2013 and 2016. Phylogenetic analysis revealed that Polish strains belonged to the C genogroup: C1, C2, and C4. Severe neurological manifestations as encephalitis or acute flaccid paralysis (AFP), were associated with all detected subgenogroups. The C2 subgenogroup was associated with the outbreak in Gdansk, with serious cases of AFP, myelitis, cerebellitis, encephalitis, but also with mild, sporadic cases of aseptic meningitis, in other Polish cities. Data from the study established relationships of EV-A71 from Poland with previously characterized strains and confirmed the importance of high quality enterovirus surveillance with international reach.

show abstract

“…Interestingly, German researchers recently described a case of paediatric encephalitis caused by a novel EV-A71 genotype that likely arose from a recombination event [60]. Although no epidemic activity of EV-A71 has so far been reported in Europe, the European Centre for Disease Prevention and Control (ECDC) risk assessment reported increased detections of EV-A71 in the first half of 2016 compared to previous years, necessitating preparedness to control its spread in Europe [61].…”

Section: Enterovirus 71 and Coxsackievirus A16mentioning

confidence: 99%

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

Anastasina

Domanska

Palm

et al. 2017

Journal of General Virology

View full text Add to dashboard Cite

Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.

show abstract

A severe pediatric infection with a novel enterovirus A71 strain, Thuringia, Germany

Cited by 37 publications

References 29 publications

Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016

Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016

Genetic characterization of enterovirus A71 isolates from severe neurological cases in Poland

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

Contact Info

Product

Resources

About