A shared threat-anticipation circuit is dynamically engaged at different moments by certain and uncertain threat
Brian R. Cornwell,
Paige R. Didier,
Shannon E. Grogans
et al.
Abstract:Temporal dynamics play a central role in models of emotion:“fear”is widely conceptualized as a phasic response to certain-and-imminent danger, whereas“anxiety”is a sustained response to uncertain-or-distal harm. Yet the underlying human neurobiology remains contentious. Leveraging an ethnoracially diverse sample, translationally relevant paradigm, and theory-driven modeling approach, we demonstrate that certain and uncertain threat recruit a shared threat-anticipation circuit. This circuit exhibits persistentl… Show more
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