A short-duration restrictive diet reduces visceral adiposity in the morbidly obese surgical patient

Cleveland, Elaine M.; Peirce, Greg; Brown, Shaun R.; Freemyer, Josiah D.; Rice, William V.; Lee, Llewellyn; Coviello, L.; Davis, Kurt G.

doi:10.1016/j.amjsurg.2016.01.040

Cited by 7 publications

(1 citation statement)

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“…This correlated also with a decrease of some biochemical parameters, including total cholesterol, triglycerides, and fasting glycaemia [216]. In line with this, two different studies on obese individuals underwent CR diet for 14 days demonstrated a significant reduction of the VAT, but not the SAT, probably due to a dissimilar responsiveness and physiological characteristic of the adipose cells in the two compartments: differently from the SAT, VAT cells display induction of lipid metabolism related genes in response to fasting [218,219]. Interestingly, when the effect of CR on body fat distribution was investigated independently or in combination with regular exercise, it emerged that the body weight reduction and the VAT loss were not statistically different between the different groups [220,221], therefore highlighting the cruciality of CR in the reduction of visceral adiposity.…”

Section: Lifestyle Interventions-let Food Be Your Medicinesupporting

confidence: 57%

Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis

2021

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The prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumulation represents a risk factor for many chronic diseases, including cancer. Adiposity, chronic low-grade inflammation, and hyperinsulinemia are essential factors of obesity that also play a crucial role in tumor onset. In recent years, several strategies have been pointed toward boundary fat accumulation, thus limiting the burden of cancer attributable to obesity. While remodeling fat via adipocytes browning seems a tempting prospect, lifestyle interventions still represent the main pathway to prevent cancer and enhance the efficacy of treatments. Specifically, the Mediterranean Diet stands out as one of the best dietary approaches to curtail visceral adiposity and, therefore, cancer risk. In this Review, the close relationship between obesity and cancer has been investigated, highlighting the biological mechanisms at the basis of this link. Finally, strategies to remodel fat, including browning and lifestyle interventions, have been taken into consideration as a major perspective to limit excess body weight and tumor onset.

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