A signal-off fluorescent strategy for deferasirox effective detection using carbon dots as probe and Cu2+ as medium

Ratiometric fluorescence assay based on carbon dots and Cu2+-catalyzed oxidation ofO-phenylenediamine for the effective detection of deferasirox

“…It is known that DEF can chelate with Cu 2+ to form DEF–Cu. 14 The formed DEF–Cu would decrease the free copper ion, and then the Cu 2+ -triggered oxidation of OPD was inhibited by the addition of DEF. The reduced oxOPD caused by DEF addition weakened the interaction and quenching effect of oxOPD on CDs with the excitation at 370 nm.…”

“… 26 Carbon dots (CDs), a new type of fluorescent carbon nanomaterials in analytical applications, 27,28 possess the advantages of controllable optical properties, water solubility, simple preparation, and facile surface functionalization. 11 Meanwhile, for specific detection applications, synthetic designs of CDs are needed with particular excitation/emission properties, 14 enhanced fluorescence quantum yield (QY), 29 and other surface properties. 13 Correspondingly, with variable sources available, several strategies including the microwave-assisted method, melting procedure, and solvothermal approach have been developed for CDs preparation with modulated physicochemical properties.…”

“… 43–47 As a metal chelating agent, DEF can chelate with Cu 2+ to form a stable complex (DEF–Cu). 14 Inspired by the fact that Cu 2+ can play dual functions of the oxidant for OPD to produce oxOPD and the chelation with DEF to form a complex, a ratiometric sensing strategy for DEF with Cu 2+ as a medium is designed for DEF detection based on the competitive role of Cu 2+ , as shown in Scheme 1 . Taking m -phenylenediamine as a source, a green luminescent CDs was prepared through a two-step process of hydrothermal synthesis and the post-treatment of HCl.…”

Quaternized carbon dots with enhanced antimicrobial ability towards Gram-negative bacteria for the treatment of acute peritonitis caused by E. coli

“…The optical properties of the QCDs also revealed features typical of carbon dots. 15,16 Fourier-transform infrared (FTIR) spectroscopy was used to characterize the functional groups of the QCDs, as shown in Fig. 1(D).…”

“…Carbon dots (CDs) have attracted increasing attention due to their controllable preparation, modulated properties, low toxicity, and potential for wide applications in the biomedical field. [14][15][16] The optimization of synthetic methods and precursors is considered the main synthetic approach to obtain CDs suitable for use in various applications. 14,17 Therefore, in the face of antibacterial resistance, antibacterial materials based on CDs have received ever-increasing attention due to their advantageous structure-property relationships.…”