A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010

Kim, Shin Hye; Huh, Kyoung; Won, Sungho; Lee, Kuk‐Wha; Park, Mijung

doi:10.1371/journal.pone.0141844

Cited by 95 publications

(103 citation statements)

References 17 publications

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“…CPP can cause early menarche in girls and result in short adult stature due to early epiphyseal fusion (11). The annual incidence of CPP in girls had significantly increased from 3.3 to 50.4 per 100,000 girls during 2004 to 2010 in Korea (28). The incidence of girls diagnosed with CPP has markedly increased in 21th century and much higher compared to 40 year ago in Denmark (29).…”

Section: Discussionmentioning

confidence: 99%

Early menarche is a risk factor of short stature in young Korean female: Epidemiologic study

Kang¹,

Kim²,

Lee³

et al. 2019

Jcrpe

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We investigated the association between age at menarche and adult height (and body mass index; BMI) in young Korean female. We also investigated whether early menarche (<12years) is a risk factor of short stature and obesity in young Korean female. Methods: We analyzed data for 1148 female aged 18-30 years (612 pairs of mothers and daughters) from the 6th Korea National Health and Nutrition Examination Survey (KNHANES IV) (2013-2015). Results: Among 1148 female, 256(22.3%) female had early menarche. Female grew approximately 0.445 cm shorter when menarche occurred 1 year earlier. The prevalence of short stature (≤153cm) u n c o r r e c t e d p r o o f and obesity(BMI≥25) was higher in female with early menarche compared with later menarche(short stature: 10.5% vs. 6.4%, obesity; 20.7% vs. 13.1%, all P < 0.001). In multivariate regression, the odds ratio (OR) of short stature was 2.62(95%CI 1.26-5.44) adjusting for current age and mother's height. However, the OR of obesity was 1.74(0.98-3.07) after adjusting for age and mother' BMI. Conclusion: The final height for female is influenced by age of menarche. Early menarche increased the risk of adult short stature in young Korean female.

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Section: Discussionmentioning

confidence: 99%

Early menarche is a risk factor of short stature in young Korean female: Epidemiologic study

Kang¹,

Kim²,

Lee³

et al. 2019

Jcrpe

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“…Future studies can help refine the use of FMV urinary gonadotropins as a diagnostic method for pubertal disorders. CPP has become a common reason for visits and referrals to pediatric endocrinologists in Korea [24]. In clinical practice, random basal serum gonadotropins are routinely used as an initial screening method for CPP.…”

Section: Discussionmentioning

confidence: 99%

Random urinary gonadotropins as a useful initial test for girls with central precocious puberty

Shim

Lee

et al. 2019

Endocr J

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Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation test to determine whether random urinary gonadotropins can be used as an alternative method for evaluating central precocious puberty (CPP). In total, 100 girls aged 6.0-8.9 years were enrolled. The subjects were divided into two groups according to their pubertal response to the GnRH stimulation test: a positive group (n = 68) and a negative group (n = 32). Random urinary luteinizing hormone (LH), follicle-stimulating hormone (FSH), and the LH:FSH ratio were significantly positively correlated with FMV urinary LH (r = 0.411, p < 0.001), FMV urinary FSH (r = 0.494, p < 0.001), and the FMV urinary LH:FSH ratio (r = 0.519, p < 0.001). The optimal cutoff values from receiver operating characteristic (ROC) curve analyses were determined to be 0.20 IU/L for random urinary LH (area under the curve (AUC) of 0.812, p < 0.001), 3.03 IU/L for random urinary FSH (AUC of 0.670, p = 0.004) and 0.08 for the random urinary LH:FSH ratio (AUC of 0.784, p < 0.001). No differences were observed between FMV and random urinary LH (p = 0.827), between FMV and random urinary FSH (p = 0.650), or between the FMV and random urinary LH:FSH ratio (p = 0.688) in ROC curve analyses with DeLong's test. Based on our findings, random urinary gonadotropins may be applicable in clinical practice as a useful initial test for girls with CPP.

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“…There has been an increase in the incidence and prevalence of precocious puberty as reported in various publications. In a study conducted in Korea, the prevalence of precocious puberty was reported as 55.9 in 100.000 girls [30] . In various studies, 86%-92% of the cases of precocious puberty consisted of female children with a female-to-male ratio ranging from 3:1 to 23:1 [31] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of normal, normal variants and precocious puberty in children referred with signs of early pubertal development to pediatric endocrine unit

Kılınç¹

2019

Haydarpasa Numune Med J

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Introduction: The aim of this study was to evaluate the etiologic distribution and clinical features of children referred to a pediatric endocrinology clinic with signs of early puberty, and to compare clinical, biochemical, and anthropometric properties of the patients followed-up with the diagnosis of precocious puberty and normal variants puberty. Methods: In this single-center study, we included children referred with signs of early puberty between July 2015 and July 2017. We retrospectively evaluated the anthropometric measurements and pubertal status of the patients. In the evaluation of patients with suspected early puberty, biochemical tests, bone age, and pelvic ultrasound were used. If indicated, a standard gonadotropin-releasing hormone stimulation test and brain magnetic resonance imaging were performed. Results: A total of 476 children were referred for evaluation of early puberty. There were 454 (95.3%) females. The mean age of the patients at the time of referral was 8.97±2.5 years for girls and 9.56±0.74 years for boys. Out of 476 children, only 139 (29.2%) had early pubertal development, and the remaining 337 (70.8%) had normal puberty or no puberty. Out of 139 patients, 45 (9.4%) had precocious puberty, 59 (12.3%) had premature thelarche, and 35 (7.3%) had premature adrenarche. Discussion and Conclusion: Most of children referred for the evaluation of early pubertal development showed normal puberty or puberty variants. This study emphasizes the importance of a good diagnostic evaluation of these patients.

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A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010

Cited by 95 publications

References 17 publications

Early menarche is a risk factor of short stature in young Korean female: Epidemiologic study

Early menarche is a risk factor of short stature in young Korean female: Epidemiologic study

Random urinary gonadotropins as a useful initial test for girls with central precocious puberty

Assessment of normal, normal variants and precocious puberty in children referred with signs of early pubertal development to pediatric endocrine unit

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