A silver carp skin derived collagen in bone defect treatment—A histological study in a rat model

Hadzik, Jakub; Kubasiewicz−Ross, Paweł; Kunert‐Keil, Christiane; Jurczyszyn, Kamil; Nawrot-Hadzik, Izabela; Dominiak, Marzena; Gedrange, Tomasz

doi:10.1016/j.aanat.2016.07.009

Cited by 28 publications

(13 citation statements)

References 26 publications

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“…These sources can serve as marine source of collagen for medicinal and industrial use . Marine collagen has recently been reported to be a novel biomaterial for cell and tissue culture as an alternative to conventional mammalian collagens such as bovine and porcine collagens . The different types of collagen obtained from marine sources over a past decade and their potential use or future applications were summarized ( Table ).…”

Section: Marine Collagenmentioning

confidence: 61%

Collagen from Marine Biological Sources and Medical Applications

Felician

Xia

et al. 2018

Chemistry & Biodiversity

218

140

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Collagen is the most studied protein with a wide range of applications including pharmaceutical, biomedical, cosmetics, leather, and film industries due to its special characteristics that are high biocompatibility, good bioactivity, and weak antigenicity. Although collagen sources are abundant, the outbreak of varied diseases among land animals posed threat to its utilization in our daily life. Thus, a probe for an alternative source began, which in turn revealed the immense untapped marine sources, such as fish, jellyfish, and some marine Mammals. The present article deals with a brief description of collagen, its characteristics, marine sources, extraction, collagen peptides and their biological activities, potential use and application in various field.

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Section: Marine Collagenmentioning

confidence: 61%

Collagen from Marine Biological Sources and Medical Applications

Felician

Xia

et al. 2018

Chemistry & Biodiversity

218

140

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“…Pengetahuan pasien dalam terapi warfarin sangat penting karena kontrol antikoagulasi dapat ditingkatkan, ditandai dengan penurunan reaksi obat merugikan dan komplikasi yang berkaitan 7 . Pasien memiliki peningkatan risiko komplikasi perdarahan seperti darah dalam urin dan memar yang tidak biasa 8 , serta melakukan rawat inap di rumah sakit sebesar 50% jika pengetahuan kesehatan yang dimiliki pasien sangat terbatas dibandingkan dengan pasien yang memiliki pengetahuan kesehatan yang memadai.…”

Section: Pendahuluanunclassified

“…Sumber-sumber ini dapat berfungsi sebagai sumber kolagen laut untuk obat-obatan dan keperluan industri 6 . Kolagen laut baru-baru ini dilaporkan sebagai biomaterial baru untuk kultur sel dan jaringan sebagai alternatif dari kolagen mamalia konvensional, seperti kolagen sapi dan babi 7 .…”

Section: Pendahuluanunclassified

Pemanfaatan Kolagen Laut dalam Sistem Penghantaran Obat

Nining

2020

Maj. Farmasetika

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Kolagen laut atau marine collagen merupakan biomaterial yang memiliki potensi besar dalam pemanfaatannya di bidang farmasi karena keberlimpahannya di alam. Penelitian mengenai sistem penghantaran obat dengan carrier kolagen laut telah banyak diteliti dan dilaporkan. Artikel ini merupakan review mengenai studi yang dilakukan dalam pemanfaatan kolagen laut dalam berbagai sistem penghantaran obat. Metode yang digunakan adalah melalui pencarian data jurnal nasional maupun internasional dengan menggunakan mesin pencari berupa Google, Google Scholar, Science Direct, Pubmed dan lainnya. Berdasarkan sumbernya, kolagen laut dikasifikasikan menjadi dua yaitu kolagen yang berasal dari invertebrata dan vertebrata. Biomaterial ini memiliki karakteristik yang unik dari segi kimia, fisika, dan biologi. Sistem penghantaran yang telah dikembangkan dan dilaporkan berupa sistem partikulat, film, gel dan hidrogel, enteric-coating tablet, serta sponge. Pengembangan sistem penghantaran obat lainnya dengan kolagen yang bersumber dari keanekaragaman hayati perikanan dan kelautan Indonesia menjadi peluang dan tantangan di masa yang akan datang.

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“…Marine collagen has been considered as an alternative to vertebral collagen for fabricating biological scaffolds. 7,8 Jellyfish is one of the major sources of marine collagen. 9 Different from the widely available vertebral collagen, which is made with collagen type I or III, Jellyfish collagen (JFC) is mainly composed of collagen that closely resembles collagen type II in vertebrates.…”

Section: Introductionmentioning

confidence: 99%

Combination of collagen scaffold with doxycycline for the treatment of cartilage and subchondral bone defects

Liang

Stein

Swami

et al. 2021

MRAJ

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The repair of cartilage and bone tissue post arthritis or injury in the knee joint is a challenge to the orthopedics. Both doxycycline and collagen scaffolds had been shown with positive influences on the repair of the tissue. Doxycycline inhibits catabolism related enzymes. Collagens provide tissue repair materials. In this study, the influence of doxycycline and jellyfish collagen (JFC) scaffold to the cells in vitro and tissue repair in vivo was studied. Doxycycline was found with a broad inhibition of the matrix metallopeptidases. It also had an enhancement to the progenitor chondrocytes but suppressed the maturation of chondrocytes. JFC (major type II collagen) was seen had improved both type I and type II collagen production during chondrogenesis of mesenchymal stem cells in vitro. Both doxycycline and JFC enhanced the bone formation and had synergistic effects in a late-stage during the bone repair process. However, the cartilage repair was found with no significant influence after the implantations. Overall, the control of metabolism by doxycycline and providing stimulation to collagen production by the implantation of JFC only contribute to bone growth but had little influence on cartilage repair. This indicates the growth of cartilage tissue needs more delicate regulation. The subchondral bone repair, even with some chondrocytes and proteoglycan deposition in the extracellular matrix could not convert to a repair with mature hyaluronic cartilage tissue.

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A silver carp skin derived collagen in bone defect treatment—A histological study in a rat model

Cited by 28 publications

References 26 publications

Collagen from Marine Biological Sources and Medical Applications

Collagen from Marine Biological Sources and Medical Applications

Pemanfaatan Kolagen Laut dalam Sistem Penghantaran Obat

Combination of collagen scaffold with doxycycline for the treatment of cartilage and subchondral bone defects

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