A Simple and Easily Reproducible Model of Reversible Obstructive Jaundice in Rats

Hiratani, Seigo; Mori, Rintaro; Ota, Yoshihide; Matsuyama, Ryusei; Kumamoto, Takafumi; Nagashima, Yoji; Morioka, Daisuke; Endo, Itaru

doi:10.21873/invivo.11528

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…Statistical analysis with One Way Annova/Kruskal Wallis followed by post hoc tests showed a significant increase in hepar function parameters between the sham group and the LDB group, as well as between the sham group and the LDB + BAL group (p<0.05). The ligation action of the biliary ductus ductus in rats of the Wistar strain Rattus novergicus caused obstructive jaundice and impaired hepar function of experimental animals, these results are in accordance with previous studies using a mouse model of obstruction jaundice (Celikkaya et al, 2019;HIRATANI et al, 2019;White et al, 2006;Zhou, 2012).…”

Section: The Effect Of Lactococcus Lactis D4 Starter Fermented Milk F...supporting

confidence: 92%

Lactococcus Lactis D4 Starter Fermented Milk’s Effect on Liver Function of Obstructive Jaundice Model

Anami

Rivai

Suchitra

et al. 2023

IJOMS

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Obstructive jaundice can cause liver function damage which exacerbates patient morbidity and mortality. Fermented milk starter Lactococcus Lactis D4 derived from dadih is a probiotic that has the potential to improve liver function through the enterohepatic pathway. The research would like to determine the effect of Lactococcus Lactis D4 starter fermented milk on liver function of obstructive jaundice. This study was an experimental study with a post test only randomized control group design in 3 groups of Rattus Novergicus strain Wistar rats with obstructive jaundice model which got ligation of biliary ducts and given Lactococcus lactis D4 starter fermented milk for 7 days. Liver function was assessed by looking at the levels of total bilirubin, SGOT, SGPT, ALP, and GGT in each treatment group. Administration of Lactococcus Lactis D4 starter fermented milk caused a decrease in SGOT levels (LDB + BAL vs LDB: 51.12 ± 1.77 U/L vs 64.63 ± 0.10 U/L, p<0.05) and SGPT (LDB + LAB vs LDB: 60.60±0.85 U/L vs 67.77±2.60 U/L, p<0.05) which was significant. However, there was no significant effect on total bilirubin levels (LDB + BAL vs LDB: 3.21±0.11 mg/dl vs 3.18±0.10 mg/dl, p>0.05), ALP (LDB + LAB vs LDB: 108.20 ± 2.78 U/L vs 115.38 ± 5.08 U/L, p>0.05), and GGT (LDB + LAB vs LDB: 12.57 ± 0.45 U/L vs 12.78±0.31 U/L, p>0.05). Lactococus Lactis D4 starter fermented milk can improve liver function which is indicated by a decrease in SGOT and SGPT levels in experimental animals.

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Section: The Effect Of Lactococcus Lactis D4 Starter Fermented Milk F...supporting

confidence: 92%

Lactococcus Lactis D4 Starter Fermented Milk’s Effect on Liver Function of Obstructive Jaundice Model

Anami

Rivai

Suchitra

et al. 2023

IJOMS

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“…This was discovered by radiographic inspection. These were brought on by the massive buildup of bile, which in turn caused the gallbladder to experience extreme pressure, allowing bile to freely flow from the liver to the duodenum [27].…”

Section: Discussionmentioning

confidence: 99%

Induction of Irreversible Liver Fibrosis by Laparoscopic Closure of Common Bile Duct in Dogs

Shekho,

Ali,

Alchalabi

2025

Egyptian Journal of Veterinary Sciences

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HIS study was aimed to assess the laparoscopic ligation of common bile duct using a titanium clip in eighteen healthy adult domestic dogs from both sexes, the age ranged from (24±6) months and weight ranged from (20±5) kg. After ligation of common bile duct, the animals were left for 21 days. All animals were subjected to evaluated progression of hepatic fibrosis by clinical, ultrasonography, radiography and laboratory examination. Clinical results such as severe abdominal pain, anorexia, emaciation, jaundice and paleness mucus membrane were observed. Ultrasonographical examination of the liver revealed dilatation of the gallbladder and common bile duct as well as an increased in thickness and echogenicity of liver texture, while the biochemical parameters at the 21 days of closure the common bile duct revealed significant elevation in liver serum enzymes and total, direct and indirect bilirubin at p≤0.05. In conclusion, the laparoscopic technique of inducing incurable liver fibrosis in dogs by surgical closure of the common bile duct with titanium clips is an unconventional, effective, less complication and straightforward technique to induce fibrosis.

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“…1-3 months after the ligation of the common bile duct, the animal dies with the phenomena of severe exhaustion. With the complete exclusion of fats from the diet, animals live longer [20,21].…”

Section: Demonstration Of Mechanical Jaundicementioning

confidence: 99%

"Methodical Approaches to Modeling the Pathology of the Digestive System in Animals"

Bon¹

2022

BJSTR

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A Simple and Easily Reproducible Model of Reversible Obstructive Jaundice in Rats

Cited by 7 publications

References 36 publications

Lactococcus Lactis D4 Starter Fermented Milk’s Effect on Liver Function of Obstructive Jaundice Model

Lactococcus Lactis D4 Starter Fermented Milk’s Effect on Liver Function of Obstructive Jaundice Model

Induction of Irreversible Liver Fibrosis by Laparoscopic Closure of Common Bile Duct in Dogs

"Methodical Approaches to Modeling the Pathology of the Digestive System in Animals"

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