A simple and efficient preconcentration method based on vortex assisted reduced graphene oxide magnetic nanoparticles for the sensitive determination of endocrine disrupting compounds in different water and baby food samples by GC-FID

Ayyıldız, Merve Fırat; Fındıkoğlu, Maral Selin; Chormey, Dotse Selali; Bakırdere, Sezgin

doi:10.1016/j.jfca.2020.103431

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…The adsorption mechanism includes van der Waals interactions or dipole-dipole intermolecular forces that hold the analyte to the adsorbent surface [25,26]. Physiochemical reaction during the complex formation might result in absorption, and a suitable technique would be required to remove the absorbed molecule [27]. SPE techniques have five essential processes: sample preparation, column conditioning, sample loading, column washing, and analyte elution.…”

Section: Gc-msmentioning

confidence: 99%

Advances of hyphenated technique in impurity profiling of active pharmaceutical ingredients and pharmaceutical products

Khandale,

Rajge,

Singh

et al. 2023

Separation Science Plus

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Impurities found in active pharmaceutical ingredients (APIs) and pharmaceutical products are of ever‐increasing interest. According to several regulatory agencies, purity and impurity profiles are essential. An impurity is defined as any additional inorganic or organic material, residual solvents other than the medicinal components, or undesired compounds that remain with APIs. Impurities and degradation products in bulk drug materials and pharmaceutical formulations are identified, their structures are clarified, and their quantitative determination is part of impurity profiling. Unrecognized, poisonous impurities are dangerous to health and should be identified by selective procedures to increase the safety of drug therapy, and impurity profiling has become more significant in pharmaceutical analysis. This review briefly introduces process and product‐related impurities and emphasizes the creation of cutting‐edge analytical techniques for identifying them. It discusses the use of analytical methods, particularly high‐performance thin‐layer chromatography, liquid chromatography with mass spectrometry (MS), ultrahigh‐performance liquid chromatography, gas chromatography–MS, and nuclear magnetic resonance spectroscopy for the identification of contaminants and degradation products. It has discussed the importance of the quality, efficacy, and safety of drug substances and products, including the origin, types, and quality control of impurities, the need for the development of impurity profiling methods, impurity identification, and regulatory aspects.

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Section: Gc-msmentioning

confidence: 99%

Advances of hyphenated technique in impurity profiling of active pharmaceutical ingredients and pharmaceutical products

Khandale,

Rajge,

Singh

et al. 2023

Separation Science Plus

View full text Add to dashboard Cite

show abstract

“…These properties give them unique characteristics, which have aroused great interest [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. These characteristics, convert NPs, specifically AgNPs, into tools used as potential applications in a wide variety of fields [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Moreover, and despite the benefits that their use can generate for the diagnosis of diseases [ 15 , 16 ] or their treatment by acting as anticancer or antimicrobial agents [ 17 ], NPs also appear on the scene as potential emerging pollutants whose effects on human health [ 9 , 18 , 19 ] and the environment are not yet fully known [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Study of the Stability of Citrate Capped AgNPs in Several Environmental Water Matrices by Asymmetrical Flow Field Flow Fractionation

et al. 2021

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Asymmetrical flow field-flow fractionation (AF4) coupled to UV-Vis and dynamic light scattering (DLS) detectors in series, was tested for stability studies of dispersions of citrate-capped silver nanoparticles (AgNPs) in several water matrices. The main goal is to provide knowledge to understand their possible behavior in the environment for short times since mixturing (up to 180 min). Ultrapure (UPW), bottled (BW1, BW2), tap (TW), transitional (TrW) and sea water (SW) matrices were assayed. Observations were compatible with the aggregation of AgNPs, a change in the plasmon band and a size growth with time were done. Fractograms showed different evolution fingerprints in the function of the waters and batches. The aggregation rate order was BW2, SW, TrW, BW1 and TW, being BW2 the lowest and TW the highest. NP aggregation can be induced by increasing the salt concentration of the medium, however transitional and sea waters did not follow the rule. Both matrices presented a lower aggregation rate in comparison with other aqueous matrices with much lower ionic strength (BW1 and TW), which can be explained by the potential presence of dissolved organic matter and/or the high concentration of halides providing their stabilization and passivation, respectively. AF4 provides relevant information with respect to static DLS and UV-Vis Spectroscopy showing that at least two populations of aggregates with different sizes between them, depending on both, the mixture time for a given matrix and type of water matrix for the same time.

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“…The xenoestrogens bisphenol A (BPA), nonylphenol (NP) and 4- tert -octylphenol (4-t-OP), which are industrially produced in high volumes [ 2 ], are often present in food packaging plastics and other materials from which they can migrate to food and water [ 1 ]. Organophosphorus pesticides, another group of EDCs, are monitored on the grounds of their adverse effects on human health [ 3 ]. Finally, parabens are widely used as antimicrobial preservatives against moulds and yeasts, as well as in cosmetics and pharmaceuticals and food and beverage processing [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Validation and Use of an Accurate, Sensitive Method for Sample Preparation and Gas Chromatography–Mass Spectrometry Determination of Different Endocrine-Disrupting Chemicals in Dairy Products

Colón

Rascón

Hejji

et al. 2021

Foods

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Endocrine disrupting chemicals (EDCs) are exogenous substances capable of altering the human hormone system and causing various diseases such as infertility and cancer as a result. In this work, a method for determining twenty-three different EDCs including parabens, alkylphenols, phenylphenols, organophosphorus pesticides, bisphenol A and triclosan in dairy products was developed. Samples are conditioned by addition of acetonitrile containing 1% formic acid, centrifugation and clean-up of the extract by continuous solid-phase extraction. EDCs in the extract are derivatised by heating in a microwave oven and quantified by gas chromatography–mass spectrometry. The proposed method features good limits of detection (6–40 ng/kg) and precision (relative standard deviation < 7.6%); also, it is scarcely subject to matrix effects (1–20%). EDC recoveries from spiked samples ranged from 80 to 108%. The method was used to analyse a total of 33 samples of dairy products including cow, sheep and goat milk, yoghourt, milkshakes, cheese, cream, butter and custard. Bisphenol A was the individual contaminant detected in the greatest number of samples, at concentrations from 180 to 4800 ng/kg. 2-Phenylphenol and ethylparaben were found in more than one-half, at concentrations over the range 130–3500 and 89–4300 ng/kg, respectively. In contrast, alkylphenols, organophosphorus pesticides and triclosan were detected in none.

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A simple and efficient preconcentration method based on vortex assisted reduced graphene oxide magnetic nanoparticles for the sensitive determination of endocrine disrupting compounds in different water and baby food samples by GC-FID

Cited by 13 publications

References 27 publications

Advances of hyphenated technique in impurity profiling of active pharmaceutical ingredients and pharmaceutical products

Advances of hyphenated technique in impurity profiling of active pharmaceutical ingredients and pharmaceutical products

Study of the Stability of Citrate Capped AgNPs in Several Environmental Water Matrices by Asymmetrical Flow Field Flow Fractionation

Validation and Use of an Accurate, Sensitive Method for Sample Preparation and Gas Chromatography–Mass Spectrometry Determination of Different Endocrine-Disrupting Chemicals in Dairy Products

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